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CD154 Antibody (F-1) is an IgG2a κ mouse monoclonal CD154 antibody (also designated CD40LG antibody, CD40L antibody, CD40 Ligand antibody, TNF-Related Activation Protein antibody, TRAP antibody, Tumor Necrosis Factor (Ligand) Superfamily Member 5 antibody, T-B Cell-Activating Molecule antibody, CD40 Antigen Ligand antibody, T-Cell Antigen Gp39 antibody, TNFSF5 antibody, HCD40L antibody, CD40-L antibody, Gp39 antibody, HIGM1 antibody, T-BAM antibody, IMD3 antibody, or IGM antibody) that detects the CD154 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CD154 Antibody (F-1) is available as both the non-conjugated anti-CD154 antibody form, as well as multiple conjugated forms of anti-CD154 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Resting B cells can be activated and clonally expanded into antibody-producing cells in response to a combination of cell contact and soluble signals provided by primed helper T (Th) cells. While cytokines IL-4 and IL-13 alone are inadequate for B cell activation, contact with Th cells seems to be sufficient for delivery of proliferative signals. CD40 and CD154 (also designated CD40L or TRAP) comprise a receptor ligand pair central to the transmission of this signal. CD40 is expressed on the surface of B cells and CD154 is expressed on activated T cells. In the presence of such stimulus, IL-4 and IL-13 are capable of triggering immunoglobulin class switching and secretion of IgE. CD154 is a 261 amino acid protein that is is expressed as a soluble cytokine as well as a homotrimeric type II transmembrane protein. Its expression is tightly regulated, and abnormal levels of CD154 are associated with the pathogenesis of atheromatous plaque destabilization and thrombotic events. Mutations in the gene encoding for CD154 are implicated in hyper-IgM immunodeficiency syndrome type 1.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD154 Antibody (F-1) | sc-374635 | 200 µg/ml | $310.00 | |||
CD154 Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-525983 | 200 µg Ab; 10 µg BP | $348.00 | |||
CD154 Antibody (F-1): m-IgG2a BP-HRP Bundle | sc-546476 | 200 µg Ab; 10 µg BP | $348.00 | |||
CD154 Antibody (F-1) AC | sc-374635 AC | 500 µg/ml, 25% agarose | $408.00 | |||
CD154 Antibody (F-1) HRP | sc-374635 HRP | 200 µg/ml | $310.00 | |||
CD154 Antibody (F-1) FITC | sc-374635 FITC | 200 µg/ml | $324.00 | |||
CD154 Antibody (F-1) PE | sc-374635 PE | 200 µg/ml | $337.00 | |||
CD154 Antibody (F-1) Alexa Fluor® 488 | sc-374635 AF488 | 200 µg/ml | $350.00 | |||
CD154 Antibody (F-1) Alexa Fluor® 546 | sc-374635 AF546 | 200 µg/ml | $350.00 | |||
CD154 Antibody (F-1) Alexa Fluor® 594 | sc-374635 AF594 | 200 µg/ml | $350.00 | |||
CD154 Antibody (F-1) Alexa Fluor® 647 | sc-374635 AF647 | 200 µg/ml | $350.00 | |||
CD154 Antibody (F-1) Alexa Fluor® 680 | sc-374635 AF680 | 200 µg/ml | $350.00 | |||
CD154 Antibody (F-1) Alexa Fluor® 790 | sc-374635 AF790 | 200 µg/ml | $350.00 | |||
CD154 (F-1) Neutralizing Peptide | sc-374635 P | 100 µg/0.5 ml | $67.00 |