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Bcl-2 Antibody (SPM117): sc-56018
- Bcl-2 Antibody (SPM117) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against a synthetic peptide corresponding to amino acids 41-54 of human Bcl-2
- recommended for detection of Bcl-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- See Bcl-2 (C-2): sc-7382 for Bcl-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bcl-2 Antibody (SPM117). This work is in progress.
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SEE ALSO...
Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xL, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phospho-rylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the anti-apoptotic influence of Bcl-2.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bcl-2 Antibody (SPM117) | sc-56018 | 200 µg/ml | $310.00 |