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C3 Antibody (A-4): sc-55458
- C3 Antibody (A-4) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 541-840 of C3 of human origin
- recommended for detection of C3 of human origin by WB, IP, IF and ELISA
- See C3 (B-9): sc-28294 for C3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for C3 Antibody (A-4) for WB applications. These reagents are now offered in bundles with C3 Antibody (A-4) (see ordering information below).
Complement C3 precursor contains complement C3 beta chain, complement C3 alpha chain, C3a anaphylatoxin, complement C3b alpha chain, complement C3c fragment, complement C3dg fragment, complement C3g fragment, complement C3d fragment and complement C3f fragment. C3a, C4a, and C5a are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage that aids in the elimination of pathogens. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis. Binding of these proteins to their respective G protein-coupled receptors (C3aR, C5aR), which are present on the surface of myeloid leukocytes, induces proinflammatory events such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3aR is expressed in brain and activated B-lymphocytes whereas C5aR is prevalent on the surface of hepatocyte, lung, smooth muscle, and endothelial cells. Upon activation, C3aR and C5aR are susceptible to rapid GRK-mediated phosphorylation and clathrin-coated vesicle targeting. C5aR utilizes the Ras-Raf-ERK1/2 cascade and couples to Gi/G16 proteins.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C3 Antibody (A-4) | sc-55458 | 200 µg/ml | $310.00 | |||
C3 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-537031 | 200 µg Ab; 10 µg BP | $348.00 | |||
C3 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-534215 | 200 µg Ab; 40 µg BP | $348.00 | |||
C3 Antibody (A-4): m-IgG2a BP-HRP Bundle | sc-547916 | 200 µg Ab; 10 µg BP | $348.00 |