HLA-DQ Antibody (B-K27): sc-65320
- HLA-DQ Antibody (B-K27) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against T4 + CTL clone HG-38
- recommended for detection of HLA-DQ of human origin by IP and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HLA-DQ Antibody (B-K27). This work is in progress.
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, DQ, DP and DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. The a one chain of HLA-DQ1 class II molecule (Ia antigen) complex can bind peptides and present them to CD4+ T lymphocytes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DQ Antibody (B-K27) | sc-65320 | 100 µg/ml | $310.00 |