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HLA-DR Antibody (ML11C11): sc-73366
- HLA-DR Antibody (ML11C11) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against NHL cells of human origin
- recommended for detection of HLA-DR on normal and neoplastic B lymphocytes of human origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See HLA-DR (520B): sc-69673 for HLA-DR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for HLA-DR Antibody (ML11C11) for WB applications. These reagents are now offered in bundles with HLA-DR Antibody (ML11C11) (see ordering information below).
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II α/β dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DR Antibody (ML11C11) | sc-73366 | 200 µg/ml | $310.00 | |||
HLA-DR Antibody (ML11C11): m-IgG Fc BP-HRP Bundle | sc-539480 | 200 µg Ab; 10 µg BP | $348.00 | |||
HLA-DR Antibody (ML11C11): m-IgG1 BP-HRP Bundle | sc-541512 | 200 µg Ab; 20 µg BP | $348.00 | |||
HLA-DR Antibody (ML11C11) FITC | sc-73366 FITC | 200 µg/ml | $324.00 | |||
HLA-DR Antibody (ML11C11) PE | sc-73366 PE | 200 µg/ml | $337.00 |