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Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (β-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HLA-DRα Antibody (DA6.147) | sc-53499 | 200 µg/ml | $310.00 | |||
HLA-DRα Antibody (DA6.147): m-IgG Fc BP-HRP Bundle | sc-536975 | 200 µg Ab; 10 µg BP | $348.00 | |||
HLA-DRα Antibody (DA6.147): m-IgGκ BP-HRP Bundle | sc-534152 | 200 µg Ab; 40 µg BP | $348.00 | |||
HLA-DRα Antibody (DA6.147): m-IgG1 BP-HRP Bundle | sc-544935 | 200 µg Ab; 20 µg BP | $348.00 |