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A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-6 Antibody (6CSP01) | sc-56061 | 200 µg/ml | $310.00 | |||
caspase-6 Antibody (6CSP01): m-IgG Fc BP-HRP Bundle | sc-537093 | 200 µg Ab; 10 µg BP | $348.00 | |||
caspase-6 Antibody (6CSP01): m-IgGκ BP-HRP Bundle | sc-534281 | 200 µg Ab; 40 µg BP | $348.00 | |||
caspase-6 Antibody (6CSP01): m-IgG1 BP-HRP Bundle | sc-544998 | 200 µg Ab; 20 µg BP | $348.00 |