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caspase-6 Antibody (7.1.65): sc-73539
- caspase-6 Antibody (7.1.65) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against the prodomain of caspase-6 of human origin
- recommended for detection of caspase-6 of human origin by WB and IP
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-6 Antibody (7.1.65) for WB applications. These reagents are now offered in bundles with caspase-6 Antibody (7.1.65) (see ordering information below).
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SEE ALSO...
A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3/ caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose)polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-6 Antibody (7.1.65) | sc-73539 | 200 µg/ml | $310.00 | |||
caspase-6 Antibody (7.1.65): m-IgG Fc BP-HRP Bundle | sc-537219 | 200 µg Ab; 10 µg BP | $348.00 | |||
caspase-6 Antibody (7.1.65): m-IgGκ BP-HRP Bundle | sc-534432 | 200 µg Ab; 40 µg BP | $348.00 |