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caspase-8 Antibody (2.1.24): sc-81657
- caspase-8 Antibody (2.1.24) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against full-length recombinant caspase-8 of human origin
- recommended for detection of caspase-8 of mouse, rat and human origin by WB and IP
- See caspase-8 (8CSP03): sc-56070 for caspase-8 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for caspase-8 Antibody (2.1.24) for WB applications. These reagents are now offered in bundles with caspase-8 Antibody (2.1.24) (see ordering information below).
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SEE ALSO...
Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A and mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex (DISC), which activates caspase-8. The actived protein is released from the complex and further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-8 Antibody (2.1.24) | sc-81657 | 200 µg/ml | $310.00 | |||
caspase-8 Antibody (2.1.24): m-IgG Fc BP-HRP Bundle | sc-539649 | 200 µg Ab; 10 µg BP | $348.00 | |||
caspase-8 Antibody (2.1.24): m-IgG1 BP-HRP Bundle | sc-541632 | 200 µg Ab; 20 µg BP | $348.00 |