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caspase-8 p18 Antibody (D-7): sc-393776
- caspase-8 p18 Antibody (D-7) is a mouse monoclonal IgG2a, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 345-374 at the C-terminus of caspase-8 p18 of human origin
- recommended for detection of p18 subunit and precursor of caspase-8 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See caspase-8 (8CSP03): sc-56070 for caspase-8 p18 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for caspase-8 p18 Antibody (D-7) for WB and IHC(P) applications. These reagents are now offered in bundles with caspase-8 p18 Antibody (D-7) (see ordering information below).
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SEE ALSO...
Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A and mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex (DISC), which activates caspase-8. The actived protein is released from the complex and further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, and may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-8 p18 Antibody (D-7) | sc-393776 | 200 µg/ml | $310.00 | |||
caspase-8 p18 Antibody (D-7): m-IgG Fc BP-HRP Bundle | sc-540910 | 200 µg Ab; 10 µg BP | $348.00 | |||
caspase-8 p18 Antibody (D-7): m-IgG2a BP-HRP Bundle | sc-546974 | 200 µg Ab; 10 µg BP | $348.00 | |||
caspase-8 p18 (D-7) Neutralizing Peptide | sc-393776 P | 100 µg/0.5 ml | $67.00 |