DSC2/3 Antibody (3G130): sc-70994

Desmogleins are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. Desmogleins belong to the cadherin family and consist of Dsg1, Dsg2, Dsg3 and Dsg4. The desmosomal cadherin desmocollins DSC1 and DSC3 are also type I membrane proteins that may contribute to epidermal cell positioning by mediating differential adhesiveness between cells that express different isoforms. Alternative splicing gives rise to isoforms A and B of DSC1 and DSC3, which differ in their C-termini. DSC2 exhibits homophilic interactions in solution, and forms heterophilic interactions with Dsg2. DSC2 and DSC1 are present at high levels in the suprabasal skin layers. Dsc2 protein is predominantly localized to specialized adhesion junctions between the cortex and the medulla. DSC3 is expressed in all living epidermal layers as well as in glandular ducts, basal matrix cells and the outer root sheath of hair follicles. DSC3, but not DSC1, is also present in desmosomes of the basal and suprabasal cell layers of other stratified epithelia such as cervix, tongue and esophagus as well as in cells of the basal layer of bladder urothelium and the complex epithelium of trachea.

The preferred DSC2/3 antibody is DSC2/3 Antibody (7G6): sc-53485.