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Integrin β2/ITGB2/CD18 Antibody (CTB104): sc-8420
- Integrin β2/ITGB2/CD18 Antibody (CTB104) is a mouse monoclonal IgG2a κ, cited in 27 publications, provided at 200 µg/ml
- raised against amino acids 1-769 representing full length Integrin β2 of human origin
- Anti-Integrin β2/ITGB2/CD18 Antibody (CTB104) is recommended for detection of Integrin β2 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
- Anti-Integrin β2/ITGB2/CD18 Antibody (CTB104) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 405 for IF, IHC(P) and FCM
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Integrin β2/ITGB2/CD18 (CTB104): sc-8420.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Integrin β2/ITGB2/CD18 Antibody (CTB104) for WB and IHC(P) applications. These reagents are now offered in bundles with Integrin β2/ITGB2/CD18 Antibody (CTB104) (see ordering information below).
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Integrin β2/ITGB2/CD18 Antibody (CTB104) is an IgG2a κ mouse monoclonal Integrin β2 antibody that detects Integrin β2 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA. Integrin β2/ITGB2/CD18 Antibody (CTB104) is available as the non-conjugated anti-Integrin β2 antibody form, as well as multiple conjugated forms of anti-Integrin β2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Human leukocytes contain a large pool of free forms of CD18. | Drbal, K., et al. 2000. Biochem Biophys Res Commun. 275: 295-9. PMID: 10964661
- Monoclonal antibodies specific for bovine CD18. | Dusinský, R., et al. 2001. Folia Biol (Praha). 47: 108-10. PMID: 11409317
- A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells. | Drbal, K., et al. 2001. Blood. 98: 1561-6. PMID: 11520808
- Integrins: versatility, modulation, and signaling in cell adhesion. | Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
- Integrins and signal transduction pathways: the road taken. | Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
- Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. | Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
- Epithelial integrins. | Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
- Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation. | Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
- Nomenclature and characterization of leukocyte differentiation antigens in ruminants. | Naessens, J., et al. 1997. Immunol Today. 18: 365-8. PMID: 9267076
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β2/ITGB2/CD18 Antibody (CTB104) | sc-8420 | 200 µg/ml | $310.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104): m-IgG Fc BP-HRP Bundle | sc-528227 | 200 µg Ab; 10 µg BP | $348.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104): m-IgGκ BP-HRP Bundle | sc-520553 | 200 µg Ab, 40 µg BP | $348.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104): m-IgG2a BP-HRP Bundle | sc-547052 | 200 µg Ab; 10 µg BP | $348.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) AC | sc-8420 AC | 500 µg/ml, 25% agarose | $408.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) HRP | sc-8420 HRP | 200 µg/ml | $310.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) FITC | sc-8420 FITC | 200 µg/ml | $324.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) PE | sc-8420 PE | 200 µg/ml | $337.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 488 | sc-8420 AF488 | 200 µg/ml | $350.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 546 | sc-8420 AF546 | 200 µg/ml | $350.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 594 | sc-8420 AF594 | 200 µg/ml | $350.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 647 | sc-8420 AF647 | 200 µg/ml | $350.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 680 | sc-8420 AF680 | 200 µg/ml | $350.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 790 | sc-8420 AF790 | 200 µg/ml | $350.00 | |||
Integrin β2/ITGB2/CD18 Antibody (CTB104) Alexa Fluor® 405 | sc-8420 AF405 | 200 µg/ml | $350.00 |