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Integrin β2/ITGB2/CD18 Antibody (6A21): sc-71398
- Integrin β2/ITGB2/CD18 Antibody (6A21) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against human leukocytes of a patient suffering from LGL-type leukemia
- recommended for detection of an epitope involving residues 534-546 in cysteine-rich repeat 3 of Integrin β2 of human origin by WB (non-reducing), IP, IF and FCM
- also provided azide-free for biological studies, sc-71398 L, 100 µg/0.1 ml
- See Integrin β2/ITGB2/CD18 (CTB104): sc-8420 for Integrin β2/ITGB2/CD18 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin β2/ITGB2/CD18 Antibody (6A21). This work is in progress.
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SEE ALSO...
Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β2/ITGB2/CD18 Antibody (6A21) | sc-71398 | 100 µg/ml | $310.00 | |||
Integrin β2/ITGB2/CD18 Antibody (6A21) L | sc-71398 L | 100 µg/0.1 ml | $310.00 |