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ICAD Antibody (B-6): sc-17818
- ICAD Antibody (B-6) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-331 representing full length ICAD of human origin
- recommended for detection of ICAD of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ICAD Antibody (B-6) for WB applications. These reagents are now offered in bundles with ICAD Antibody (B-6) (see ordering information below).
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The CED/ICE family of cysteine proteases plays a pivotal role in mediating apoptosis through the proteolysis of specific targets. Among the targets are poly (ADP-ribose) polymerase (PARP), gelsolin, DFF-45/ICAD and the nuclear lamins. PARP is a nuclear protein that is specifically cleaved by CPP32 and Mch2, but not by ICE, into a signature apoptotic fragment. Gelsolin is cleaved by CPP32 to an active form that severs actin filaments in a Ca++-independent manner. In addition to binding actin, gelsolin can form complexes with fibronectin, which may be important for localizing gelsolin to inflammatory sites. DFF-45/ICAD, the subunit of DNA fragmentation factor, is cleaved by CPP32 to generate an active factor that induces DNA fragmentation. The nuclear Lamin A is cleaved by Mch2, but not CPP32. Nuclear Lamin B is fragmented as a consequence of apoptosis by an unidentified member of the ICE family.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAD Antibody (B-6) | sc-17818 | 200 µg/ml | $310.00 | |||
ICAD Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-536592 | 200 µg Ab; 10 µg BP | $348.00 | |||
ICAD Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-533745 | 200 µg Ab; 40 µg BP | $348.00 | |||
ICAD Antibody (B-6): m-IgG2b BP-HRP Bundle | sc-549815 | 200 µg Ab; 10 µg BP | $348.00 |