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XIAP Antibody (A-7): sc-55550
- XIAP Antibody (A-7) is a mouse monoclonal IgG1 κ XIAP antibody, cited in 33 publications, provided at 200 µg/ml
- raised against amino acids 1-202 mapping at the N-terminus of XIAP of human origin
- XIAP Antibody (A-7) is recommended for detection of XIAP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-XIAP Antibody (A-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of XIAP (A-7): sc-55550.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for XIAP Antibody (A-7) for WB and IHC(P) applications. These reagents are now offered in bundles with XIAP Antibody (A-7) (see ordering information below).
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SEE ALSO...
XIAP Antibody (A-7) is an IgG1 κ mouse monoclonal XIAP antibody (also designated inhibitor of apoptosis protein 3 (IAP3) antibody, baculoviral IAP repeat-containing protein 4 (BIRC4) antibody, TRAF1/TRAF2 binding protein antibody, or baculovirus IAP repeat-containing apoptotic suppressor protein antibody) that detects the XIAP protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. XIAP Antibody (A-7) is available as both the non-conjugated anti-XIAP antibody form, as well as multiple conjugated forms of anti-XIAP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the immune system of the host. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include XIAP and survivin. XIAP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtublules of the mitotic spindle. In-creased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
XIAP Antibody (A-7) | sc-55550 | 200 µg/ml | $310.00 | |||
XIAP Antibody (A-7): m-IgG Fc BP-HRP Bundle | sc-528599 | 200 µg Ab; 10 µg BP | $348.00 | |||
XIAP Antibody (A-7): m-IgGκ BP-HRP Bundle | sc-521015 | 200 µg Ab, 40 µg BP | $348.00 | |||
XIAP Antibody (A-7): m-IgG1 BP-HRP Bundle | sc-543019 | 200 µg Ab; 20 µg BP | $348.00 | |||
XIAP Antibody (A-7) AC | sc-55550 AC | 500 µg/ml, 25% agarose | $408.00 | |||
XIAP Antibody (A-7) HRP | sc-55550 HRP | 200 µg/ml | $310.00 | |||
XIAP Antibody (A-7) FITC | sc-55550 FITC | 200 µg/ml | $324.00 | |||
XIAP Antibody (A-7) PE | sc-55550 PE | 200 µg/ml | $337.00 | |||
XIAP Antibody (A-7) Alexa Fluor® 488 | sc-55550 AF488 | 200 µg/ml | $350.00 | |||
XIAP Antibody (A-7) Alexa Fluor® 546 | sc-55550 AF546 | 200 µg/ml | $350.00 | |||
XIAP Antibody (A-7) Alexa Fluor® 594 | sc-55550 AF594 | 200 µg/ml | $350.00 | |||
XIAP Antibody (A-7) Alexa Fluor® 647 | sc-55550 AF647 | 200 µg/ml | $350.00 | |||
XIAP Antibody (A-7) Alexa Fluor® 680 | sc-55550 AF680 | 200 µg/ml | $350.00 | |||
XIAP Antibody (A-7) Alexa Fluor® 790 | sc-55550 AF790 | 200 µg/ml | $350.00 |