Recombinant Human AMHR2 293 Cell Lysate
| Cat.No. : | AMHR2-8883HCL |
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| Description : | Antigen standard for anti-Mullerian hormone receptor, type II (AMHR2), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
| Source : | HEK 293 cells |
| Species : | Human |
| Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
| Size : | 0.1 mg |
| Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
| Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
| Gene Name : | AMHR2 anti-Mullerian hormone receptor, type II [ Homo sapiens ] |
| Official Symbol : | AMHR2 |
| Synonyms : | AMHR2; anti-Mullerian hormone receptor, type II; anti-Muellerian hormone type-2 receptor; MISR2; MISRII; M?llerian inhibiting substance type II receptor; AMH type II receptor; MIS type II receptor; anti-Muellerian hormone type II receptor; Mullerian inhibiting substance type II receptor; AMHR; MRII; |
| Gene ID : | 269 |
| mRNA Refseq : | NM_001164690 |
| Protein Refseq : | NP_001158162 |
| MIM : | 600956 |
| UniProt ID : | Q16671 |
| Chromosome Location : | 12q13 |
| Pathway : | ALK2 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; |
| Function : | ATP binding; hormone binding; metal ion binding; nucleotide binding; receptor activity; transforming growth factor beta receptor activity, type II; |
Products Types
| ◆ Recombinant Protein | ||
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| AMHR2-10H | Recombinant Human AMHR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Amhr2-474M | Recombinant Mouse Amhr2 Protein, MYC/DDK-tagged | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMHR2 is involved in the development and maintenance of male and female reproductive organs, including the testes, ovaries, and genital ducts.
Mutations or dysregulation of AMHR2 can lead to reproductive abnormalities, such as persistent M眉llerian duct syndrome or disorders of sexual development.
AMHR2 plays a crucial role in mediating the AMH-induced regression of M眉llerian ducts in male embryos, allowing for the development of the male reproductive system.
Besides its role in the reproductive system, AMHR2 may have additional functions in non-reproductive tissues or diseases, highlighting its potential as a therapeutic target beyond reproduction.
AMHR2 signaling pathways may cross-talk with other signaling pathways, such as the Wnt/尾-catenin or Notch pathways, to fine-tune reproductive processes and organ development.
AMHR2 expression can be influenced by genetic variations and epigenetic modifications that contribute to inter-individual differences in AMHR2 levels.
AMHR2 forms a complex with AMH ligand and the co-receptor, AMH receptor type 2 (ACVR2A), to initiate signaling cascades.
AMHR2 expression is regulated by various factors during embryonic development and tissue-specific differentiation, including transcription factors and hormonal cues.
Modulating AMHR2 signaling pathways may hold therapeutic potential for managing reproductive disorders characterized by abnormal M眉llerian duct development or function.
AMHR2 activates the Smad signaling pathway, leading to downstream gene expression changes involved in reproductive organ development and maintenance.
Customer Reviews (3)
Write a reviewReliable detection of protein-protein interaction dynamics.
Accurate determination of protein complex composition.
Compatibility with challenging sample types (e.g., crude extracts).
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