BTD Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P43251 |
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Other Accession | NP_000051 |
Clone Names | 80102143 |
Gene ID | 686 |
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Other Names | Biotinidase, Biotinase, BTD |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP7752a was selected from the N-term region of human BTD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BTD (HGNC:1122) |
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Function | Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation. |
Cellular Location | Secreted, extracellular space |
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Provided below are standard protocols that you may find useful for product applications.
Background
Biotinidase (BTD) functions to recycle biotin in the body by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. Biotinidase has also been shown to have biotinyl-transferase activity. Defects in the biotinidase gene cause multiple carboxylase deficiency.
References
Milankovics,I., Mol. Genet. Metab. 90 (3), 345-348 (2007)Wolf,B., Hum. Mutat. 25 (4), 413 (2005)
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