Recombinant Human MYC, His-tagged
| Cat.No. : | MYC-38H |
| Product Overview : | Recombinant Human MYC (Pro2-Ala439), fused with N-terminal 6x histidine tag, was expressed in E.coli. |
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| Description : | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
| Source : | E.coli |
| Species : | Human |
| Tag : | His |
| Form : | Lyophilized powder. Lyophilized from a 0.2 µm filtered solution in PBS. |
| Molecular Mass : | 51 kDa |
| Endotoxin : | Not determined |
| Purity : | >85% |
| Applications : | ELISA, EIA, Western Blotting, Dot Blotting, Immunoprecipitation, Protein Array, Functional Assay, etc. |
| Storage : | Upon arrival, the lyophilized protein may be stored for 2 weeks at 4°C. For long term storage, it is recommended to store desiccated below -20°C in a manual defrost freezer. Following reconstitution, the protein may be stored for 2 weeks under sterile conditions at -20°C. For long term storage, it is recommended to make appropriate aliquots and store at -80°C. Avoid repeated freeze-thaw cycles. |
| Preservative : | None |
| Reconstitution : | Briefly spin the vial and bring the contents to the bottom prior to opening. It is recommended to reconstitute at 0.5~1.17 mg/mL with sterile deionized water. |
| Shipping : | Upon arrival, the lyophilized products may be stored for 2 weeks at 4 °C. For long term storage, it is recommended to be stored desiccated below -20 °C in a manual defrost freezer. Following reconstitution, the protein may be stored for 2 weeks under sterile conditions at 4 °C. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA) and store at -20 °C or -80 °C in appropriate aliquots. Avoid repeated freeze-thaw cycles. |
| Gene Name : | MYC v-myc myelocytomatosis viral oncogene homolog (avian) [ Homo sapiens ] |
| Official Symbol : | MYC |
| Synonyms : | MYC; MRTL; c-Myc; bHLHe39; myc proto-oncogene protein; OTTHUMP00000158589; OTTHUMP0000022- 7763; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelo- cytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor; Proto-oncoge- ne c-Myc; Transcription factor p64; Class E basic helix-loop-helix protein 39 |
| Gene ID : | 4609 |
| mRNA Refseq : | NM_002467 |
| Protein Refseq : | NP_002458 |
| MIM : | 190080 |
| UniProt ID : | P01106 |
| Chromosome Location : | 8q24.21 |
| Pathway : | Acute myeloid leukemia; C-MYC pathway; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| Function : | DNA binding; E-box binding; protein binding; sequence-specific DNA binding transcription factor activity |
Products Types
| ◆ Recombinant Protein | ||
| MYC-1461H | Recombinant Human MYC Protein, His (Fc)-Avi-tagged | +Inquiry |
| MYC-2735R | Recombinant Rhesus Macaque MYC Protein, His (Fc)-Avi-tagged | +Inquiry |
| MYC-5787H | Recombinant Human MYC Protein, GST-tagged | +Inquiry |
| MYC-3498R | Recombinant Rat MYC Protein, His (Fc)-Avi-tagged | +Inquiry |
| MYC-32H | Recombinant Active Human c-Myc Protein (1-454) | +Inquiry |
| ◆ Lysates | ||
| MYC-4039HCL | Recombinant Human MYC 293 Cell Lysate | +Inquiry |
| ◆ Assay kits | ||
| Kit-1785 | Myc Reporter Kit (Myc Signaling Pathway) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAbnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.
Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.
The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.
Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.
MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.
Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.
Customer Reviews (3)
Write a reviewThe reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.
Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.
Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.
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