Recombinant Human ACLY, GST-tagged
Cat.No. : | ACLY-9291H |
Product Overview : | Recombinant Human ACLY protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 751-1101a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | ACLY ATP citrate lyase [ Homo sapiens ] |
Official Symbol : | ACLY |
Synonyms : | ACLY; ATP citrate lyase; ATP-citrate synthase; ACL; ATP citrate synthase; ATPCL; CLATP; citrate cleavage enzyme; ATP-citrate (pro-S-)-lyase; |
Gene ID : | 47 |
mRNA Refseq : | NM_001096 |
Protein Refseq : | NP_001087 |
MIM : | 108728 |
UniProt ID : | P53396 |
Chromosome Location : | 17q21.2 |
Pathway : | ChREBP activates metabolic gene expression, organism-specific biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; |
Function : | ATP binding; ATP citrate synthase activity; binding; ligase activity; metal ion binding; nucleotide binding; succinate-CoA ligase (ADP-forming) activity; transferase activity; |
Products Types
◆ Recombinant Protein | ||
ACLY-0220H | Recombinant Human ACLY Protein (M1-M1101), Tag Free | +Inquiry |
ACLY-1907H | Recombinant Human ACLY Protein (4-265 aa), His-SUMO-tagged | +Inquiry |
Acly-252M | Recombinant Mouse Acly Protein, MYC/DDK-tagged | +Inquiry |
ACLY-420H | Active Recombinant Human ACLY Protein, GST-tagged | +Inquiry |
ACLY-0221H | Recombinant Human ACLY Protein (M1-M1101), His tagged | +Inquiry |
◆ Lysates | ||
ACLY-509HCL | Recombinant Human ACLY cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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