Recombinant Human Actin, Gamma 1, T7-tagged
Cat.No. : | ACTG1-60H |
Product Overview : | Recombinant Human actin, gamma 1 produced inE.Colicontains T7 tag at N-terminus and is purified by proprietary chromatographic techniques. |
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Cat. No. : | ACTG1-60H |
Description : | Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in nonmuscle cells. Recombinant Human ACTG-1 produced in E.Coli is a non-glycosylated, polypeptide chain containing amino acids (1-375) and having a total molecular mass of 41.8 kda. |
Source : | E. coli. |
Purity : | Greater than 95.0% as determined by the analysis by reducing and non-reducing SDS-PAGE coomassie blue staining. |
Physical Appearance : | Sterile Filtered clear solution. |
Formulation : | Recombinant Human Actin Gamma 1 at a concentration of 2mg/ml in 10mM Tris, pH 8.0, 0.1% Triton X-100 and 0.002% NaN3. |
Applications : | • ELISA • MS • Inhibition Assays • Western Blotting. |
Storage : | rhACTG-1 although stable at 14°Cfor 1 week, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | ACTG1 actin, gamma 1 [ Homo sapiens ] |
Synonyms : | ACT; ACTG; DFNA20; DFNA26; ACTG1;actin, gamma 1 propeptide; actin, cytoplasmic 2; cytoskeletal gamma-actin; Gamma-actin; ACTB; ACTG |
Gene ID : | 71 |
mRNA Refseq : | NM_001614 |
Protein Refseq : | NP_001605 |
MIM : | 102560 |
UniProt ID : | P63261 |
Chromosome Location : | 17q25 |
Pathway : | Adherens junction; Arrhythmogenic right ventricular cardiomyopathy (ARVC); Focal adhesion; Hypertrophic cardiomyopathy (HCM); Leukocyte transendothelial migration; Pathogenic Escherichia coli infection - EHEC; Regulation of actin cytoskeleton; Tight junction; Vibrio cholerae infection |
Function : | structural constituent of cytoskeleton; identical protein binding; nucleotide binding; ATP binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionACTG1 plays a crucial role in cytoskeletal dynamics, cell division, cell migration, and maintaining cell shape.
ACTG1 mutation leads to hearing loss in humans.
GO function and pathway enrichment analysis suggest that inflammatory response plays a crucial role in IDD based on differentially expressed genes (DEGs) from microarray datasets.
Yes, bioinformatics analysis suggests that ACTG1 might be a hub gene in IDD.
It is proposed that ACTG1 regulates the fitness of uterine cancer cells by modulating cell-intrinsic properties and the tumor microenvironment.
ACTG1 regulates the development of IDD through the NF-κB-p65 and Akt pathways.
ACTG1 gains in uterine cancers are associated with transcriptional patterns reflecting activation of oncogenic signals, repression of response to innate immunity, or immunotherapy.
In the protein-protein interaction (PPI) network, ACTG1 is connected to proteins involved in inflammation-related pathways.
The knockdown of ACTG1 suppresses the proliferation and migration of tumor cells.
Yes, the low expression of ACTG1 is also found in degenerated NP tissues in rats.
Yes, ACTG1 mutations can be inherited in an autosomal dominant pattern, which means that one copy of the mutated gene is sufficient to cause the condition.
Depletion of ACTG1 in human NP cells increases MMP3 expression, decreases collagen II levels, and leads to excessive apoptosis, exacerbating IDD.
ACTG1's functions relative to other actomyosin genes support the notion that it is a potential biomarker and a target gene in precision therapies for uterine cancer.
Yes, based on the findings, ACTG1 may serve as a novel marker and therapeutic target for IDD in the future.
Uterine cancers, including mixed endometrial carcinomas, serous carcinomas, endometroid carcinomas, and carcinosarcomas, have the highest frequencies of ACTG1 gene amplification or overexpression.
Patients with ACTG1 gains in uterine cancers have a poor prognosis.
The ACTG1 gene encodes the protein actin gamma-1, which is involved in cell structure and movement.
The expression of ACTG1 is low in severely degenerated nucleus pulposus (NP) tissues compared to mildly degenerated samples. The ACTG1 level is negatively correlated with human disc degeneration grades.
The deletion of ACTG1 using CRISPR-CAS9 gene editing has robust and consistent effects on uterine cancer cells, indicating its functional importance in these cells compared to 20 other lineages.
Yes, mutations in ACTG1 have been linked to conditions such as Baraitser-Winter syndrome and nonsyndromic hearing loss.
Customer Reviews (5)
Write a reviewThe functional assays using the protein product consistently yield strong and reproducible signals, indicating its high efficacy.
The protein product was carefully packaged, with appropriate cold-chain shipping to maintain its stability and integrity.
It shows remarkable lot-to-lot consistency, ensuring reliable and reproducible experimental outcomes.
The protein product exhibits exceptional stability, maintaining its structural integrity even under challenging experimental conditions.
The company's representatives were knowledgeable and provided valuable guidance on experimental protocols and optimization.
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