Recombinant Human CACNB4, His-tagged
| Cat.No. : | CACNB4-10640H |
| Product Overview : | Recombinant Human CACNB4 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
| Unit | |
| Price | |
| Qty |
- Specification
- Gene Information
- Related Products
- Download
| Description : | This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : | E.coli |
| Species : | Human |
| Tag : | His |
| Protein length : | 1-350a.a. |
| Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
| Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
| Gene Name : | CACNB4 calcium channel,voltage-dependent,beta 4 subunit [ Homo sapiens ] |
| Official Symbol : | CACNB4 |
| Synonyms : | CACNB4;Cavβ4 Calcium Channel;EA5;EJM;calcium channel,voltage-dependent,beta 4 subunit;CAB4;EIG9;EJM4;EJM6;CACNLB4;voltage-dependent L-type calcium channel subunit beta-4;calcium channel voltage-dependent subunit beta 4;dihydropyridine-sensitive L-type,cal |
| Gene ID : | 785 |
| mRNA Refseq : | NM_000726 |
| Protein Refseq : | NP_000717 |
| MIM : | 601949 |
| UniProt ID : | O00305 |
| Chromosome Location : | 2q22-q23 |
| Pathway : | rrhythmogenic right ventricular cardiomyopathy (ARVC);Axon guidance;Cardiac muscle contraction;Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels;Developmental Biology;Dilated cardiomyopathy;Hypertrophic cardiomyopathy (HCM) |
| Function : | contributes_to high voltage-gated calcium channel activity;protein binding;contributes_to voltage-gated calcium channel activity;voltage-gated ion channel activity |
Products Types
| ◆ Recombinant Protein | ||
| CACNB4-431R | Recombinant Rhesus Macaque CACNB4 Protein, His (Fc)-Avi-tagged | +Inquiry |
| Cacnb4-738M | Recombinant Mouse Cacnb4 Protein, MYC/DDK-tagged | +Inquiry |
| CACNB4-0274H | Recombinant Human CACNB4 Protein, GST-Tagged | +Inquiry |
| CACNB4-056H | Recombinant Human CACNB4 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
| CACNB4-603R | Recombinant Rhesus monkey CACNB4 Protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| CACNB4-7902HCL | Recombinant Human CACNB4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionCACNB4 serves as an auxiliary subunit that influences the activity, surface expression, and trafficking of voltage-gated calcium channels.
CACNB4 is widely expressed, with significant concentrations in neural tissues and the retina.
CACNB4 mainly interacts with the alpha-1 subunit of calcium channels, and may also associate with other proteins in specific cellular contexts.
CACNB4 can affect the channel's gating properties, potentially modifying calcium ion entry into cells during depolarization events.
Post-translational modifications such as phosphorylation might be present on CACNB4, influencing its function or protein-protein interactions.
Specific mutations in the CACNB4 gene can alter its regulatory activity, affecting calcium channel behavior and related physiological processes.
Dysfunctions or mutations in CACNB4 have been associated with conditions like episodic ataxia and certain types of epilepsy.
Customer Reviews (3)
Write a reviewAffordable protein assays, ideal for our budget.
Trustworthy source for all protein-related needs.
Effortless protein purification, thanks to their guidance.
Ask a Question for All CACNB4 Products
Required fields are marked with *
My Review for All CACNB4 Products
Required fields are marked with *
Inquiry Basket
