Recombinant Human CBL
| Cat.No. : | CBL-26492TH |
| Product Overview : | Recombinant full length Human CBL protein with an N terminal proprietary tag; predicted mwt: 125.73 kDa inclusive of tag. |
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| Description : | The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. |
| Protein length : | 906 amino acids |
| Molecular Weight : | 125.730kDa inclusive of tags |
| Source : | Wheat germ |
| Form : | Liquid |
| Purity : | Proprietary Purification |
| Storage buffer : | pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : | MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHH HHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNS PPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFME NLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSH MLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIV PWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFE FDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKAR LQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPH NKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDH IKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLM CTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSG SLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVER PPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTAS KAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRP QRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPV SAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGST FSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARP LPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRAC DCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHA NTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSF GWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSC QQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVI AQNNIEMAKNILREFVSISSPAHVAT |
| Sequence Similarities : | Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.Contains 1 RING-type zinc finger.Contains 1 UBA domain. |
| Gene Name : | CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence [ Homo sapiens ] |
| Official Symbol : | CBL |
| Synonyms : | CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; CBL2; E3 ubiquitin-protein ligase CBL; c Cbl; oncogene CBL2; RNF55; |
| Gene ID : | 867 |
| mRNA Refseq : | NM_005188 |
| Protein Refseq : | NP_005179 |
| MIM : | 165360 |
| Uniprot ID : | P22681 |
| Chromosome Location : | 11q23.3-qter |
| Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; Chronic myeloid leukemia, organism-specific biosystem; |
| Function : | SH3 domain binding; calcium ion binding; ephrin receptor binding; ligase activity; phosphotyrosine binding; |
Products Types
| ◆ Recombinant Protein | ||
| Cbl-788M | Recombinant Mouse Cbl Protein, MYC/DDK-tagged | +Inquiry |
| CBL-513H | Recombinant Human CBL Protein, His (Fc)-Avi-tagged | +Inquiry |
| CBL-466R | Recombinant Rhesus Macaque CBL Protein, His (Fc)-Avi-tagged | +Inquiry |
| CBL-2727H | Recombinant Human CBL Protein, MYC/DDK-tagged | +Inquiry |
| CBL-197H | Recombinant Human CBL Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
| ◆ Lysates | ||
| CBL-287HCL | Recombinant Human CBL cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (4)
Ask a questionThere are three subtypes of CBL, which are respectively C-CBL, CBL-b and CBL-3.
CBL negatively regulates tyrosine kinase activity in tumor cells and is involved in tumor invasion.
CBL proteins function as ligands and E3 ubiquitin ligases, targeting and degrading a range of proteins.
CBL consists of a tyrosine kinase binding region at the N-terminus, a ring finger region, a proline-rich motif, threonine and tyrosine phosphorylation sites, and a C-terminus with ubiquitin ligase activity.
Customer Reviews (3)
Write a reviewPrompt delivery helped me get satisfactory experimental results in a short period of time.
The CBL proteins purchased from your company is suitable for WB.
The high quality of the purchased protein helped me to obtain satisfactory experimental results.
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