Recombinant Human CD28 Molecule
| Cat.No. : | CD28-1593H |
- Specification
- Gene Information
- Related Products
- Download
| Cat. No. : | CD28-1593H |
| Description : | CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. It is expressed on the cell surface as disulfide-linked homodimer or as monomer. CD28 is the receptor for B7.1 (CD80) and B7.2 (CD86). When activated by Toll-like receptor ligands, the B7.1 expression is upregulated in antigen presenting cells (APCs). The B7.2 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. Stimulation through CD28 in addition to the TCR can provide a potent co-stimulatory signal to T cells for the production of various interleukins (IL-2 and IL-6 in particular). CD28 possesses an intracellular domain with several residues that are critical for its effective signalling. CD28 also contains two proline-rich motifs that are able to bind SH3-containing proteins. CD28 has also been found to stimulate eosinophil granulocytes where its ligation with anti-CD28 leads to the release of IL-2, IL4, IL-13 and IFN-γ. |
| Molecular Weight : | The predicted molecular weight of Recombinant Human CD28 is Mr 42.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60-70 kDa. |
| Source : | Mammalian cells |
| State Of Matter : | Lyophilized. |
| Purity : | >95% by SDS Page and analyzed by silver stain. |
| Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
| Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
| SDS-PAGE: |
|
| Gene Name : | CD28 CD28 molecule [ Homo sapiens ] |
| Synonyms : | CD28; CD28 molecule; Tp44; MGC138290; CD28 antigen; CD28 antigen (Tp44); T-cell-specific surface glycoprotein |
| Gene ID : | 940 |
| mRNA Refseq : | NM_006139 |
| Protein Refseq : | NP_006130 |
| MIM : | 186760 |
| UniProt ID : | P10747 |
| Chromosome Location : | 2q33 |
| Pathway : | Allograft rejection; Autoimmune thyroid disease; Cell adhesion molecules (CAMs); Graft-versus-host disease; Systemic lupus erythematosus; T cell receptor signaling pathway; Type I diabetes mellitus |
| Function : | SH3/SH2 adaptor activity; coreceptor activity; identical protein binding |
Products Types
| ◆ Recombinant Protein | ||
| CD28-0774H | Recombinant Human CD28 Protein, GST-Tagged | +Inquiry |
| CD28-0773H | Recombinant Human CD28 Protein, His-Flag-StrepII-Tagged | +Inquiry |
| CD28-625M | Recombinant Mouse CD28 Protein, Fc-tagged | +Inquiry |
| CD28-1204C | Active Recombinant Cynomolgus CD28 protein(Met1-Pro152), hFc-tagged | +Inquiry |
| CD28-32H | Active Recombinant Human CD28 protein, Biotin-labelled | +Inquiry |
| ◆ Lysates | ||
| CD28-2002MCL | Recombinant Mouse CD28 cell lysate | +Inquiry |
| CD28-2013HCL | Recombinant Human CD28 cell lysate | +Inquiry |
| ◆ Assay kits | ||
| Kit-1705 | CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionCD28 protein expression and function may be relevant for personalized treatment strategies in autoimmune diseases and cancer.
Targeting CD28 protein may have therapeutic potential in treating autoimmune diseases, cancer immunotherapy, and organ transplantation.
CD28 signaling is important for the function and maintenance of regulatory T cells, which play a role in immune tolerance and suppression of autoimmunity.
CD28 protein is involved in enhancing the anti-tumor immune response, making it a potential target for cancer immunotherapy.
Currently, there are no FDA-approved therapies specifically targeting CD28 protein, but research is ongoing in this area.
Customer Reviews (3)
Write a reviewIts unique characteristics contribute to obtaining clear and detailed structural information, enabling researchers to unravel the intricate complexities of protein interactions and conformational changes.
Researchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
the CD28 protein's outstanding performance in ELISA and its utility in protein electron microscopy structure analysis make it a highly recommended tool for researchers.
Ask a Question for All CD28 Products
Required fields are marked with *
My Review for All CD28 Products
Required fields are marked with *
Inquiry Basket
