Recombinant Human Cell Division Cycle 25 Homolog C (S. pombe), GST-tagged
| Cat.No. : | CDC25C-1576H |
| Product Overview : | Full-length recombinant human CDC25C was expressed in Sf9 insect cells using an N-terminal GST tag. |
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| Cat. No. : | CDC25C-1576H |
| Description : | CDC25C (also known as cell division cycle 25 homolog C) is a member of the CDC25 phosphatase family. CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. CDC25C activates the partially purified p34 (cdc2)/cyclin B complex and directs the dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. CDC25C also suppresses p53-induced growth arrest. The regulation of CDC25B phosphorylation by p38 is a critical event for initiating the G2/M checkpoint after ultraviolet radiation. |
| Applications : | Phosphatase Assay; Western Blot |
| Molecular Weight : | 84 kDa |
| Expression System : | Sf9 insect cells using baculovirus |
| Species : | Human |
| Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol. |
| Specific Activity : | 22 nmol/min/mg |
| Purity : | > 70 % |
| Concentration : | 0.1 ug/ul |
| Sequences : | Full-length |
| Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Pathways : | Activation of ATR in response to replication stress; Cell Cycle Checkpoints; Cell Cycle, Mitotic; Cell cycle; Cyclin A/B1 associated events during G2/M transition; Cyclin B2 mediated events; G2/M Checkpoints; G2/M DNA damage checkpoint; G2/M Transition; Monoamine Transport; Oocyte meiosis; PLK1 signaling events; PLK3 signaling events; Polo-like kinase mediated events; Progesterone-mediated oocyte maturation |
| SDS-PAGE: |
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| Gene Name : | CDC25C cell division cycle 25 homolog C (S. pombe) [ Homo sapiens ] |
| Official Symbol : | CDC25C |
| Synonyms : | CDC25C; cell division cycle 25 homolog C (S. pombe); M-phase inducer phosphatase 3; OTTHUMP00000159490; cell division cycle 25C; dual specificity phosphatase CDC25C; mitosis inducer CDC25; phosphotyrosine phosphatase; CDC25; EC 3.1.3.48 |
| Gene ID : | 995 |
| mRNA Refseq : | NM_001790 |
| Protein Refseq : | NP_001781 |
| MIM : | 157680 |
| UniProt ID : | P30307 |
| Chromosome Location : | 5q31 |
| Function : | WW domain binding; hydrolase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity |
Products Types
| ◆ Recombinant Protein | ||
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| CDC25C-2676H | Recombinant Human CDC25C protein, His-tagged | +Inquiry |
| CDC25C-27900TH | Recombinant Human CDC25C | +Inquiry |
| ◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
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03/02/2023
Fast and timely shipment helped me to get satisfactory experimental results in short time.
08/16/2022
The staff was very nice, communicated with me positively and solved a lot of technical problems.
03/12/2022
The technician gave me a thorough introduction to the CDC25C protein so that I could understand its biochemical properties.
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