Active Recombinant Human COMP protein(Met1-Ala757), His-tagged
| Cat.No. : | COMP-674H |
| Product Overview : | Recombinant Human COMP (NP_000086.2) precusor (Met 1-Ala 757) was expressed in HEK293 with a C-terminal polyhistidine tag. |
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| Source : | HEK293 |
| Species : | Human |
| Tag : | C-His |
| Protein length : | Met1-Ala757 |
| Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Bio-activity : | Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells. When cells are added to COMP-coated plates (0.625 μg/mL and 100 μL/well), approximately >30% cells will adhere specifically after 60 minutes at 37°C. |
| Molecular Mass : | The mature form of human COMP consists of 748 amino acids after removal of the signal peptide and predicts a molecular mass of 82.4 kDa. As a result of glycosylation, the apparent molecular mass of rhCOMP is approximately 120-130 kDa in SDS-PAGE under reducing conditions. |
| Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Purity : | > 80 % as determined by SDS-PAGE |
| Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
| Gene Name : | COMP cartilage oligomeric matrix protein [ Homo sapiens ] |
| Official Symbol : | COMP |
| Synonyms : | COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); EDM1; EPD1; PSACH; MGC131819; MGC149768; |
| Gene ID : | 1311 |
| mRNA Refseq : | NM_000095 |
| Protein Refseq : | NP_000086 |
| MIM : | 600310 |
| UniProt ID : | P49747 |
Products Types
| ◆ Recombinant Protein | ||
| COMP-01H | Recombinant Human COMP Protein, His-tagged | +Inquiry |
| Comp-825R | Recombinant Rat Comp Protein, His-tagged | +Inquiry |
| COMP-1879M | Recombinant Mouse COMP Protein, His (Fc)-Avi-tagged | +Inquiry |
| COMP-185H | Recombinant Human COMP Protein, His-tagged | +Inquiry |
| COMP-1185R | Recombinant Rat COMP Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Lysates | ||
| COMP-3031HCL | Recombinant Human COMP cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCOMP levels are typically assessed through blood tests or synovial fluid analysis.
Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.
Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.
Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.
Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.
Customer Reviews (3)
Write a reviewOne of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.
The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.
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