Recombinant Human COMP, GST-tagged
Cat.No. : | COMP-11451H |
Product Overview : | Recombinant Human COMP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 407-757a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | COMP cartilage oligomeric matrix protein [ Homo sapiens ] |
Official Symbol : | COMP |
Synonyms : | COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); EDM1; EPD1; PSACH; MGC131819; MGC149768; |
Gene ID : | 1311 |
mRNA Refseq : | NM_000095 |
Protein Refseq : | NP_000086 |
MIM : | 600310 |
UniProt ID : | P49747 |
Chromosome Location : | 19p13.1 |
Pathway : | ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; |
Function : | calcium ion binding; collagen binding; extracellular matrix structural constituent; heparan sulfate proteoglycan binding; heparin binding; protein binding; |
Products Types
◆ Recombinant Protein | ||
Comp-921M | Recombinant Mouse Comp Protein, MYC/DDK-tagged | +Inquiry |
COMP-1879M | Recombinant Mouse COMP Protein, His (Fc)-Avi-tagged | +Inquiry |
COMP-01H | Recombinant Human COMP Protein, His-tagged | +Inquiry |
COMP-185H | Recombinant Human COMP Protein, His-tagged | +Inquiry |
COMP-674H | Active Recombinant Human COMP protein(Met1-Ala757), His-tagged | +Inquiry |
◆ Lysates | ||
COMP-3031HCL | Recombinant Human COMP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCOMP levels are typically assessed through blood tests or synovial fluid analysis.
Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.
Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.
Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.
Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.
Customer Reviews (3)
Write a reviewOne of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.
The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.
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