Recombinant Human COMP, His-tagged
| Cat.No. : | COMP-3658H |
| Product Overview : | Total 783 AA. MW: 85.75 kDa (calculated). C-Terminal His-tag+myc-epitope. |
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| Cat. No. : | COMP-3658H |
| Description : | Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene. The protein encoded by this gene is a noncollagenous extracellular matrix protein. It consists of five identical glycoprotein subunits. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. COMP is a marker of cartilage turnover. |
| Source : | CHO |
| Species : | Human |
| Form : | Frozen in production medium. |
| Research topic : | Bone and cartilage metabolism |
| Reconstitution : | Defrost at ambient temperature. |
| Applications : | Drug discovery; In vitro diagnostic |
| Quality Control Test : | SDS-PAGE; ELISA test |
| Sequences of amino acids : | AAQPARRAVR SFCVLLLTLA ALGASGQGQS PLGSDLGPQM LRELQETNAA LQDVRELLRQ QVREITFLKN TVMECDACGM QQSVRTGLPS VRPLLHCAPG FCFPGVACIQ TESGARCGPC PAGFTGNGSH CTDVNECNAH PCFPRVRCIN TSPGFRCEAC PPGYSGPTHQ GVGLAFAKAN KQVCTDINEC ETGQHNCVPN SVCINTRGSF QCGPCQPGFV GDQASGCQRR AQRFCPDGSP SECHEHADCV LERDGSRSCV CAVGWAGNGI LCGRDTDLDG FPDEKLRCPE RQCRKDNCVT VPNSGQEDVD RDGIGDACDP DADGDGVPNE KDNCPLVRNP DQRNTDEDKW GDACDNCRSQ KNDDQKDTDQ DGRGDACDDD IDGDRIRNQA DNCPRVPNSD QKDSDGDGIG DACDNCPQKS NPDQADVDHD FVGDACDSDQ DQDGDGHQDS RDNCPTVPNS AQEDSDHDGQ GDACDDDDDN DGVPDSRDNC RLVPNPGQED ADRDGVGDVC QDDFDADKVV DKIDVCPENA EVTLTDFRAF QTVVLDPEGD AQIDPNWVVL NQGREIVQTM NSDPGLAVGY TAFNGVDFEG TFHVNTVTDD DYAGFIFGYQ DSSSFYVVMW KQMEQTYWQA NPFRAVAEPG IQLKAVKSST GPGEQLRNAL WHTGDTESQV RLLWKDPRNV GWKDKKSYRW FLQHRPQVGY IRVRFYEGPE LVADSNVVLD TTMRGGRLGV FCFSQENIIW ANLRYRCNDT IPEDYETARG GPEQKLISEE DLNSAVDHHH HHH |
| Storage : | Store frozen at -20°C. Stable until expiry date. |
| Pathways : | ECM-receptor interaction; Focal Adhesion; Focal adhesion; Malaria; Phagosome; TGF-beta signaling pathway |
| SDS-PAGE: |
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| Gene Name : | COMP cartilage oligomeric matrix protein [ Homo sapiens ] |
| Official Symbol : | COMP |
| Synonyms : | COMP; cartilage oligomeric matrix protein; MED; EDM1; EPD1; PSACH; THBS5; MGC131819; MGC149768; cartilage oligomeric matrix protein; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); Cartilage oligomeric matrix protein; Thrombospondin-5 |
| Gene ID : | 1311 |
| mRNA Refseq : | NM_000095 |
| Protein Refseq : | NP_000086 |
| MIM : | 600310 |
| UniProt ID : | P49747 |
| Chromosome Location : | 19p13.1 |
| Function : | calcium ion binding; collagen binding; extracellular matrix structural constituent; heparan sulfate proteoglycan binding; heparin binding; protein binding |
Products Types
| ◆ Recombinant Protein | ||
| COMP-1687H | Recombinant Human COMP Protein, GST-tagged | +Inquiry |
| COMP-1185R | Recombinant Rat COMP Protein, His (Fc)-Avi-tagged | +Inquiry |
| Comp-825R | Recombinant Rat Comp Protein, His-tagged | +Inquiry |
| COMP-01H | Recombinant Human COMP Protein, His-tagged | +Inquiry |
| COMP-1879M | Recombinant Mouse COMP Protein, His (Fc)-Avi-tagged | +Inquiry |
| ◆ Lysates | ||
| COMP-3031HCL | Recombinant Human COMP cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCOMP levels are typically assessed through blood tests or synovial fluid analysis.
Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.
Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.
Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.
Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.
Customer Reviews (3)
Write a reviewOne of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.
The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.
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