Recombinant Human COMP protein, FLAG-tagged
| Cat.No. : | COMP-3659H |
| Product Overview : | Recombinant Human COMP fused with FLAG tag at N-terminal was expressed in HEK293. |
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| Description : | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). |
| Source : | HEK293 |
| Species : | Human |
| Tag : | FLAG |
| Form : | Filtered (0.4 μm) and lyophilized from 0.5 mg/ml in 20mM Tris buffer, 50mM NaCl, pH 7.5 |
| Molecular Mass : | 82.4 kDa (calculated) |
| Protein length : | 750 AA |
| AA Sequence : | HVDYKDDDDK PAGQGQSPLG SDLGPQMLRE LQETNAALQD VRELLRQQVR EITFLKNTVM ECDACGMQQS VRTGLPSVRP LLHCAPGFCF PGVACIQTES GARCGPCPAG FTGNGSHCTD VNECNAHPCF PRVRCINTSP GFRCEACPPG YSGPTHQGVG LAFAKANKQV CTDINECETG QHNCVPNSVC INTRGSFQCG PCQPGFVGDQ ASGCQRRAQR FCPDGSPSEC HEHADCVLER DGSRSCVCAV GWAGNGILCG RDTDLDGFPD EKLRCPERQC RKDNCVTVPN SGQEDVDRDG IGDACDPDAD GDGVPNEKDN CPLVRNPDQR NTDEDKWGDA CDNCRSQKND DQKDTDQDGR GDACDDDIDG DRIRNQADNC PRVPNSDQKD SDGDGIGDAC DNCPQKSNPD QADVDHDFVG DACDSDQDQD GDGHQDSRDN CPTVPNSAQE DSDHDGQGDA CDDDDDNDGV PDSRDNCRLV PNPGQEDADR DGVGDVCQDD FDADKVVDKI DVCPENAEVT LTDFRAFQTV VLDPEGDAQI DPNWVVLNQG REIVQTMNSD PGLAVGYTAF NGVDFEGTFH VNTVTDDDYA GFIFGYQDSS SFYVVMWKQM EQTYWQANPF RAVAEPGIQL KAVKSSTGPG EQLRNALWHT GDTESQVRLL WKDPRNVGWK DKKSYRWFLQ HRPQVGYIRV RFYEGPELVA DSNVVLDTTM RGGRLGVFCF SQENIIWANL RYRCNDTIPE DYETHQLRQA |
| Endotoxin : | < 0.1 EU/ug |
| Purity : | Purity as determined by densitometric image analysis: >90% |
| Applications : | Cell culture and/or animal studies, ELISA, Western blotting |
| Storage : | Store lyophilized protein at –80 centigrade. Lyophilized protein remains stable until the expiry date when stored at –80 centigrade. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at –80 centigrade for long term storage. Reconstituted protein can be stored at 4 centigrade for a limited period of time; it does not show any change after one week at 4 centigrade. |
| Reconstitution : | Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Filter sterilize your culture media/working solutions containing this non-sterile product before using in cell culture. |
| Publication : |
Secretory cargo sorting by Ca 2+-dependent Cab45 oligomerization at the trans-Golgi network. (2016)
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| Gene Name : | COMP cartilage oligomeric matrix protein [ Homo sapiens ] |
| Official Symbol : | COMP |
| Synonyms : | COMP; cartilage oligomeric matrix protein; cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple) , EDM1, EPD1, PSACH; MED; THBS5; thrombospondin 5; TSP5; thrombospondin-5; pseudoachondroplasia (epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple); cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple); EDM1; EPD1; PSACH; MGC131819; MGC149768; |
| Gene ID : | 1311 |
| mRNA Refseq : | NM_000095 |
| Protein Refseq : | NP_000086 |
| MIM : | 600310 |
| UniProt ID : | P49747 |
| Chromosome Location : | 19p13.1 |
| Pathway : | ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; |
| Function : | calcium ion binding; collagen binding; extracellular matrix structural constituent; heparan sulfate proteoglycan binding; heparin binding; protein binding; |
Products Types
| ◆ Recombinant Protein | ||
| COMP-1687H | Recombinant Human COMP Protein, GST-tagged | +Inquiry |
| COMP-674H | Active Recombinant Human COMP protein(Met1-Ala757), His-tagged | +Inquiry |
| COMP-185H | Recombinant Human COMP Protein, His-tagged | +Inquiry |
| Comp-825R | Recombinant Rat Comp Protein, His-tagged | +Inquiry |
| Comp-921M | Recombinant Mouse Comp Protein, MYC/DDK-tagged | +Inquiry |
| ◆ Lysates | ||
| COMP-3031HCL | Recombinant Human COMP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCOMP levels are typically assessed through blood tests or synovial fluid analysis.
Yes, while COMP levels are indicative of joint diseases, they are often used alongside other diagnostic tools for a comprehensive assessment.
Monitoring changes in COMP levels can be valuable in assessing the effectiveness of treatments targeting joint diseases.
Given its involvement in joint diseases, COMP might be a target for drug development, but this area requires further exploration.
Elevated COMP levels often correlate with more rapid disease progression in arthritis, aiding in prognosis.
Customer Reviews (3)
Write a reviewOne of the standout factors that distinguishes the COMP protein is the manufacturer's unwavering commitment to exceptional technical support.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the COMP protein is an invaluable tool for researchers.
The COMP protein offers exceptional quality that meets the rigorous demands of experimental research.
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