Active Recombinant Human CR1 protein, His-tagged
| Cat.No. : | CR1-506H |
| Product Overview : | Recombinant Human CR1(Gln42-Asp1971) fused with a C-terminal 10-His tag and a substitution of His1208Arg was expressed in NS0. |
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| Source : | Mammalian cells |
| Species : | Human |
| Tag : | His |
| Predicted N Terminal : | Gln42 predicted |
| Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Bio-activity : | Measured by its binding ability in a functional ELISA. When rhCD35 is coated at 5 μg/mL, complement component C3b binds with an apparent KD <10 nM. |
| Molecular Mass : | Predicted Molecular Mass: 213 kDa;SDS-PAGE: 200-220 kDa, reducing conditions. |
| Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method |
| Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain |
| Storage : | Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Reconstitution : | Reconstitute at 400 μg/mL in PBS. |
| Gene Name : | CR1 complement component (3b/4b) receptor 1 (Knops blood group) [ Homo sapiens ] |
| Official Symbol : | CR1 |
| Synonyms : | CR1; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3b/4b) receptor 1, including Knops blood group system; complement receptor type 1; CD35; KN; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component receptor 1; C3BR; C4BR; |
| Gene ID : | 1378 |
| mRNA Refseq : | NM_000573 |
| Protein Refseq : | NP_000564 |
| MIM : | 120620 |
| UniProt ID : | P17927 |
| Chromosome Location : | 1q32 |
| Pathway : | Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem; |
| Function : | complement component C3b binding; complement component C3b receptor activity; complement component C4b binding; complement component C4b receptor activity; receptor activity; |
Products Types
| ◆ Recombinant Protein | ||
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| CR1-4018H | Recombinant Human CR1 Protein (Met1-Asp1971), C-His tagged | +Inquiry |
| CR1-507H | Recombinant Human CR1 Protein, His-tagged | +Inquiry |
| CR1-2726H | Recombinant Human CR1 protein, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (4)
Ask a questionCR1 is involved in the study of systemic lupus erythematosus and Alzheimer's disease.
CR1 is predominantly expressed on peripheral blood cell membranes.
CR1 plays a role in Aβ clearance, neuroinflammation, and taurine lesions.
CR1 consists of four major structural domains: 41aa signaling peptide, extracellular structural domain, 25aa transmembrane structural domain, and 43aa cytoplasmic structural domain.
Customer Reviews (3)
Write a reviewThe CR1 protein product received was as advertised, top quality and good value for money.
The staff actively communicated with me and solved many technical problems.
The technician gave me a thorough introduction to the CR1 protein so that I could understand its biochemical properties.
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