Active Recombinant Human DAG1 Protein, His-tagged
Cat.No. : | DAG1-549H |
Product Overview : | Recombinant Human DAG1 (Accession # NP_004384) Met1-Val749, fused with with a C-terminal 6-His tag, was produced in Mouse myeloma cell line, NS0-derived. |
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Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Gln28 predicted ( alpha subunit): No results obtained, sequencing might be blocked & Ser654 ( beta subunit) |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by the ability of the immobilized protein to enhance the adhesion of H4 human neuroglioma cells.The ED50 for this effect is typically 1.5 - 6.0 µg/mL. Optimal dilutions should be determined by each laboratory for each application. |
Molecular Mass : | Recombinant Human DAG1, His-tagged has a calculated MW of 67.8 kDa ( alpha subunit) & 11.3 kDa ( beta subunit). In SDS-PAGE migrates as 65-90 kDa & 20 kDa, reducing conditions. |
Protein length : | Met1-Val749 |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Reconstitution : | Reconstitute at 100 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Gene Name : | DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) [ Homo sapiens ] |
Official Symbol : | DAG1 |
Synonyms : | DAG1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystroglycan; 156DAG; A3a; AGRNR; alpha dystroglycan; beta dystroglycan; DAG; dystrophin associated glycoprotein 1; MDDGC7; FLJ51254; |
Gene ID : | 1605 |
mRNA Refseq : | NM_001165928 |
Protein Refseq : | NP_001159400 |
MIM : | 128239 |
UniProt ID : | Q14118 |
Chromosome Location : | 3p21 |
Products Types
◆ Recombinant Protein | ||
DAG1-999R | Recombinant Rhesus Macaque DAG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Dag1-689M | Recombinant Mouse Dag1 Protein, His-tagged | +Inquiry |
DAG1-13H | Recombinant Human DAG1 Protein (28-651), Fc-tagged | +Inquiry |
DAG1-2774H | Recombinant Human DAG1 Protein, His (Fc)-Avi-tagged | +Inquiry |
DAG1-09H | Active Recombinant Human DAG1 Protein (Gln28-Val749), C-Fc-tagged | +Inquiry |
◆ Lysates | ||
DAG1-7082HCL | Recombinant Human DAG1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, mouse models with mutations in the DAG1 gene are commonly used to study the pathophysiology of DAG1-related muscle disorders.
Symptoms can include muscle weakness, hypotonia, and developmental delay, as well as eye and brain abnormalities in some cases.
DAG1 protein forms a complex with other proteins and glycoproteins to anchor the muscle cell membrane to the extracellular matrix.
Studies are exploring the potential use of DAG1 protein levels as a diagnostic and prognostic biomarker for muscle disorders.
DAG1 protein forms a complex with dystrophin, sarcoglycans, and other proteins to maintain the stability of the muscle cell membrane.
Customer Reviews (3)
Write a reviewBy utilizing the DAG1 protein in my experiments, I can trust that I am working with a product of the highest caliber, backed by a company dedicated to delivering exceptional quality and support.
The reliability and reproducibility of the DAG1 Protein's performance make it a go-to option for WB experiments.
The DAG1 protein is of exceptional quality and will undoubtedly meet my experimental needs with utmost reliability and accuracy.
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