Recombinant Human Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, His-tagged
| Cat.No. : | FCER1A-311H |
| Product Overview : | FCER1A, 26-205aa, Human, His tag, E.coli |
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| Description : | The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. FCER1A represents the alpha subunit. Recombinant human FCER1A protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Source : | E.coli |
| Species : | Human |
| Tag : | His-tag |
| Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
| Molecular Mass : | 23.4kDa (203aa) confirmed by MALDI-TOF |
| AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSVPQKPKV SLNPPWNRIF KGENVTLTCN GNNFFEVSST KWFHNGSLSE ETNSSLNIVN AKFEDSGEYK CQHQQVNESE PVYLEVFSDW LLLQASAEVV MEGQPLFLRC HGWRNWDVYK VIYYKDGEAL KYWYENHNIS ITNATVEDSG TYYCTGKVWQ LDYESEPLNI TVIKAPREKY WLQ |
| Purity : | >85% by SDS - PAGE |
| Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| Concentration : | 0.25mg/ml (determined by Bradford assay) |
| Gene Name : | FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens ] |
| Official Symbol : | FCER1A |
| Synonyms : | FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; FcERI; |
| Gene ID : | 2205 |
| mRNA Refseq : | NM_002001 |
| Protein Refseq : | NP_001992 |
| MIM : | 147140 |
| UniProt ID : | P12319 |
| Chromosome Location : | 1q23 |
| Pathway : | Asthma, organism-specific biosystem; Asthma, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem; |
| Function : | IgE binding; receptor activity; |
Products Types
| ◆ Recombinant Protein | ||
| FCER1A-25H | Active Recombinant Human FCER1A Protein (26-205aa), C-His tagged | +Inquiry |
| FCER1A-2099H | Recombinant Human FCER1A Protein (26-205 aa), His-tagged | +Inquiry |
| FCER1A-338H | Recombinant Human FCER1A Protein(Val26-Gln205), His-tagged | +Inquiry |
| FCER1A-567H | Recombinant Human FCER1A Protein (Met1-Gln205) | +Inquiry |
| FCER1A-8563H | Recombinant Human FCER1A protein(Met1-Gln205), His-tagged | +Inquiry |
| ◆ Lysates | ||
| FCER1A-1394HCL | Recombinant Human FCER1A cell lysate | +Inquiry |
| FCER1A-1389MCL | Recombinant Mouse FCER1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionModulation of FCER1A expression can be achieved through techniques such as gene knockout, gene silencing, or gene transduction. In addition, its expression levels can also be affected by altering environmental factors such as nutrition, inflammation, etc.
The expression level of FCER1A can be detected by gene expression profiling or immunohistochemistry.
FCER1A plays a key role in the immune system, recognizing and presenting antigens to T cell receptors, thereby initiating an adaptive immune response.
Studies have shown that FCER1A is associated with the risk of some autoimmune diseases, inflammatory diseases, and certain cancers.
Studying FCER1A can help to gain insight into the mechanisms of immune response and inflammatory response, which is of great significance for the development of new drugs and therapeutic strategies. In addition, it is also of great value for understanding the pathogenesis and prevention of diseases.
FCER1A has complex associations with other genes and proteins, such as its interaction with T cell receptors, inflammatory factors, etc.
Customer Reviews (3)
Write a reviewFCER1A can maintain its biological activity and structural integrity under specific experimental conditions.
FCER1A quality is stable and reliable, with no significant differences between batches.
FCER1A has high chemical and physical stability and is suitable for long-term storage and use.
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