Recombinant Human FCER1A, His-tagged
| Cat.No. : | FCER1A-204H |
| Product Overview : | Recombinant Human FCER1A, fused with a polyhistidine tag at the C-terminus, was expressed in human 293 cells (HEK293). |
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| Description : | The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | His |
| Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization. |
| Molecular Mass : | Biotinylated rh FCER1A is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 21.9 kDa. The predicted N-terminus is Val 26. DTT-reduced Protein migrates as 40-60 kDa in SDS-PAGE due to glycosylation. |
| Endotoxin : | Less than 1.0 EU per μg of the Biotinylated rh FCER1A by the LAL method. |
| Purity : | >95% as determined by SDS-PAGE. |
| Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
| Reconstitution : | See Certificate of Analysis for reconstitution instructions and specific concentrations. |
| Gene Name : | FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens (human) ] |
| Official Symbol : | FCER1A |
| Synonyms : | FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; FcERI |
| Gene ID : | 2205 |
| mRNA Refseq : | NM_002001 |
| Protein Refseq : | NP_001992 |
| MIM : | 147140 |
| UniProt ID : | P12319 |
| Chromosome Location : | 1q23 |
| Pathway : | Asthma; Fc epsilon RI signaling pathway; Fc epsilon receptor (FCERI) signaling; Immune System |
| Function : | IgE binding; IgE receptor activity |
Products Types
| ◆ Recombinant Protein | ||
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| FCER1A-1209H | Recombinant Human FCER1A Protein, His-SUMO-tagged | +Inquiry |
| FCER1A-245H | Recombinant Human FCER1A Protein, His-tagged | +Inquiry |
| FCER1A-2929H | Recombinant Human FCER1A Protein, His (Fc)-Avi-tagged | +Inquiry |
| FCER1A-25H | Active Recombinant Human FCER1A Protein (26-205aa), C-His tagged | +Inquiry |
| ◆ Lysates | ||
| FCER1A-1389MCL | Recombinant Mouse FCER1A cell lysate | +Inquiry |
| FCER1A-1394HCL | Recombinant Human FCER1A cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionModulation of FCER1A expression can be achieved through techniques such as gene knockout, gene silencing, or gene transduction. In addition, its expression levels can also be affected by altering environmental factors such as nutrition, inflammation, etc.
The expression level of FCER1A can be detected by gene expression profiling or immunohistochemistry.
FCER1A plays a key role in the immune system, recognizing and presenting antigens to T cell receptors, thereby initiating an adaptive immune response.
Studies have shown that FCER1A is associated with the risk of some autoimmune diseases, inflammatory diseases, and certain cancers.
Studying FCER1A can help to gain insight into the mechanisms of immune response and inflammatory response, which is of great significance for the development of new drugs and therapeutic strategies. In addition, it is also of great value for understanding the pathogenesis and prevention of diseases.
FCER1A has complex associations with other genes and proteins, such as its interaction with T cell receptors, inflammatory factors, etc.
Customer Reviews (3)
Write a reviewFCER1A can maintain its biological activity and structural integrity under specific experimental conditions.
FCER1A quality is stable and reliable, with no significant differences between batches.
FCER1A has high chemical and physical stability and is suitable for long-term storage and use.
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