Recombinant Human GALT, His-tagged
| Cat.No. : | GALT-7122H |
| Product Overview : | Recombinant human GALT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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| Description : | GALT catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.5) containing 0.2M NaCl, 10% glycerol. |
| Molecular Mass : | 45.9 kDa (403aa) |
| Protein length : | 1-379aa |
| AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSHMSRSGT DPQQRQQASE ADAAAATFRA NDHQHIRYNP LQDEWVLVSA HRMKRPWQGQ VEPQLLKTVP RHDPLNPLCP GAIRANGEVN PQYDSTFLFD NDFPALQPDA PSPGPSDHPL FQAKSARGVC KVMCFHPWSD VTLPLMSVPE IRAVVDAWAS VTEELGAQYP WVQIFENKGA MMGCSNPHPH CQVWASSFLP DIAQREERSQ QAYKSQHGEP LLMEYSRQEL LRKERLVLTS EHWLVLVPFW ATWPYQTLLL PRRHVRRLPE LTPAERDDLA SIMKKLLTKY DNLFETSFPY SMGWHGAPTG SEAGANWNHW QLHAHYYPPL LRSATVRKFM VGYEMLAQAQ RDLTPEQAAE RLRALPEVHY HLGQKDRETA TIA |
| Purity : | >85% by SDS - PAGE |
| Applications : | SDS-PAGE |
| Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
| Concentration : | 0.25 mg/ml |
| Gene Name : | GALT galactose-1-phosphate uridylyltransferase [ Homo sapiens ] |
| Official Symbol : | GALT |
| Synonyms : | GALT; galactose-1-phosphate uridylyltransferase; gal-1-P uridylyltransferase; galactose-1-phosphate uridyl transferase; UDP-glucose--hexose-1-phosphate uridylyltransferase; |
| Gene ID : | 2592 |
| mRNA Refseq : | NM_000155 |
| Protein Refseq : | NP_000146 |
| MIM : | 606999 |
| UniProt ID : | P07902 |
| Chromosome Location : | 9p13 |
| Pathway : | Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; Galactose catabolism, organism-specific biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; |
| Function : | UDP-glucose:hexose-1-phosphate uridylyltransferase activity; metal ion binding; nucleotidyltransferase activity; transferase activity; zinc ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTreatment for GALT deficiency involves a strict lactose-free diet, which means avoiding milk, dairy products, and other foods containing galactose.
Individuals with GALT deficiency are recommended to avoid galactose-containing foods, and dietary supplementation with essential nutrients may be necessary.
Yes, if left untreated, GALT deficiency can lead to long-term complications such as liver damage, cognitive impairment, and reproductive issues.
Yes, GALT enzyme activity levels can be measured in the blood to diagnose GALT deficiency.
Symptoms of galactosemia include jaundice, poor feeding, vomiting, liver enlargement, and failure to thrive in infants. In older children and adults, symptoms may include cognitive impairment, speech difficulties, and ovarian insufficiency in females.
Customer Reviews (3)
Write a reviewThe GALT Protein is an exceptional product that fully meets my experimental needs.
Its versatility and reliability make it a top choice for researchers in various fields.
The GALT Protein's adaptability has significantly expanded the scope of my investigations and broadened the possibilities for my research.
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