Recombinant Human HBB, GST-tagged
Cat.No. : | HBB-13679H |
Product Overview : | Recombinant Human HBB protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-147a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | HBB hemoglobin, beta [ Homo sapiens ] |
Official Symbol : | HBB |
Synonyms : | HBB; hemoglobin, beta; hemoglobin subunit beta; beta globin; CD113t C; HBD; beta globin chain; hemoglobin beta chain; CD113t-C; beta-globin; |
Gene ID : | 3043 |
mRNA Refseq : | NM_000518 |
Protein Refseq : | NP_000509 |
UniProt ID : | P68871 |
Chromosome Location : | 11p15.5 |
Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; Hemostasis, organism-specific biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; |
Function : | contributes_to haptoglobin binding; heme binding; hemoglobin binding; metal ion binding; oxygen binding; oxygen transporter activity; contributes_to peroxidase activity; protein binding; |
Products Types
◆ Native Protein | ||
HBB-001H | Native Human Hemoglobin S, Ferrous Stabilized | +Inquiry |
HBb-49S | Native Sheep Hemoglobin Beta (HBb) Protein | +Inquiry |
◆ Lysates | ||
HBB-5622HCL | Recombinant Human HBB 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionHBB, part of the hemoglobin molecule, is crucial for oxygen transport in the blood.
Therapies targeting HBB mutations aim to correct or compensate for the defective hemoglobin in blood disorders.
HBB mutations can lead to abnormal hemoglobin, resulting in impaired oxygen transport and cell damage.
It forms part of hemoglobin's structure, binding oxygen in red blood cells.
Altered HBB expression affects hemoglobin's efficiency, impacting oxygen delivery and health.
HBB interacts with other hemoglobin subunits to form a functional oxygen-carrying complex.
Mutations in HBB cause sickle cell anemia and thalassemia, affecting hemoglobin's function.
Customer Reviews (3)
Write a reviewHelps us reach milestones. Efficient and accurate service.
Critical for success. Trusted for precise protein analysis.
Supports groundbreaking discoveries. Highly recommended for research.
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