Recombinant Human major histocompatibility complex, class II, DR alpha, His-tagged
| Cat.No. : | HLA-DRA-490H |
| Product Overview : | HLA-DRA, 26-216aa Human, His tag, E.coli |
- Specification
- Gene Information
- Related Products
- Download
| Description : | Major histocompatibility complex, class II, DR alpha, also known as HLA-DRA, binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Recombinant human HLA-DRA, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Source : | E.coli |
| Species : | Human |
| Tag : | His-tag |
| Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT |
| Molecular Mass : | 24.3 kDa (212aa) confirmed by MALDI-TOF |
| AA Sequence : | MGSSHHHHHH SSGLVPRGSH MIKEEHVIIQ AEFYLNPDQS GEFMFDFDGD EIFHVDMAKK ETVWRLEEFG RFASFEAQGA LANIAVDKAN LEIMTKRSNY TPITNVPPEV TVLTNSPVEL REPNVLICFI DKFTPPVVNV TWLRNGKPVT TGVSETVFLP REDHLFRKFH YLPFLPSTED VYDCRVEHWG LDEPLLKHWE FDAPSPLPET TE |
| Purity : | >90% by SDS - PAGE |
| Storage : | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| Concentration : | 0.5 mg/ml (determined by Bradford assay) |
| Gene Name : | HLA-DRA major histocompatibility complex, class II, DR alpha [ Homo sapiens ] |
| Official Symbol : | HLA-DRA |
| Synonyms : | HLA-DRA; major histocompatibility complex, class II, DR alpha; HLA DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; MLRW; HLA-DRA1; FLJ51114; |
| Gene ID : | 3122 |
| mRNA Refseq : | NM_019111 |
| Protein Refseq : | NP_061984 |
| MIM : | 142860 |
| UniProt ID : | P01903 |
| Chromosome Location : | 6p21.3 |
| Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; |
| Function : | MHC class II receptor activity; |
Products Types
| ◆ Recombinant Protein | ||
| HLA-DRA-353H | Recombinant Human HLA-DRA Protein, His-tagged | +Inquiry |
| HLA-DRA-2300H | Recombinant Human HLA-DRA Protein (26-254 aa), His-tagged | +Inquiry |
| HLA-DRA-3571H | Recombinant Human HLA-DRA Protein (Lys27-Glu216), His tagged | +Inquiry |
| HLA-DRA-231H | Recombinant Human HLA-DRA protein, GST-tagged | +Inquiry |
| HLA-DRA-5321H | Recombinant Human HLA-DRA protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| HLA-DRA-5501HCL | Recombinant Human HLA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionHLA-DRA protein can present tumor-associated antigen fragments to immune cells during tumor immunity, thereby activating the immune response, which is of great significance for tumor immunotherapy.
Immunohistochemistry, flow cytometry, Western blot and other techniques can be used to detect the expression level of HLA-DRA protein.
The HLA-DRA protein is mainly involved in the antigen presentation process in the immune system, mediating the antigen fragment to T cells, thereby triggering an immune response against the antigen.
There is an association between polymorphisms of HLA-DRA proteins and the occurrence of certain diseases, as different HLA-DRA genotypes may affect the effectiveness of immune responses and thus susceptibility to diseases.
Yes, due to the important role of HLA-DRA protein in the immune system, it is considered a potential immunotherapy target that can be used to improve therapeutic strategies for immune diseases.
Yes, HLA-DRA protein is associated with the occurrence and development of infectious diseases such as viral and bacterial infections because it is involved in regulating the immune response and affecting the outcome of infection.
Customer Reviews (3)
Write a reviewBoth purity and biological activity are commendable.
It provides a strong guarantee for the accuracy of the experimental results.
Wide range of applications and provides support for scientific research.
Ask a Question for All HLA-DRA Products
Required fields are marked with *
My Review for All HLA-DRA Products
Required fields are marked with *
Inquiry Basket
