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Recombinant Human PC, GST-tagged

Cat.No. : PC-1545H
Product Overview : Recombinant Human PC protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Source : E.coli
Species : Human
Tag : GST
Protein length : 828-1178aa
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : PC pyruvate carboxylase [ Homo sapiens ]
Official Symbol : PC
Synonyms : PC; pyruvate carboxylase; pyruvate carboxylase, mitochondrial; PCB; pyruvic carboxylase;
Gene ID : 5091
mRNA Refseq : NM_000920
Protein Refseq : NP_000911
MIM : 608786
UniProt ID : P11498
Chromosome Location : 11q13.4-q13.5
Pathway : Alanine and aspartate metabolism, organism-specific biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Gluconeogenesis, organism-specific biosystem; Glucose metabolism, organism-specific biosystem; Glycolysis and Gluconeogenesis, organism-specific biosystem;
Function : ATP binding; biotin binding; biotin carboxylase activity; carboxylic acid binding; ligase activity; metal ion binding; nucleotide binding; pyruvate carboxylase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between the structure and function of PC proteins? 10/06/2023

The structure of the PC protein determines its ability and stability to bind to DNA. The study of its structure can help us understand its function and mechanism of action.

What are the therapeutic strategies for PC protein? 02/03/2023

Therapeutic strategies for PC protein may include inhibiting its expression, blocking its binding to DNA, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.

What is the specific role of PC protein in cancer? 11/13/2022

In cancer, PC proteins may play a role by promoting processes such as DNA replication, repair, and regulation of the cell cycle, thus promoting tumor growth and spread. It could be a potential target for cancer treatment.

What factors should be considered for drug development targeting PC proteins? 08/13/2022

Drug development targeting PC proteins needs to consider their specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

How do PC proteins interact with other proteins? 12/17/2020

The proteins can interact with a variety of other proteins, including DNA repair enzymes, cell cycle regulators, and more. These interactions allow it to regulate the regulatory processes of DNA replication, repair and the cell cycle.

Is there a correlation between PC protein expression and disease? 02/03/2020

Recently published articles indicate that the expression level of PC protein is related to the occurrence and development of certain cancers. The highly expressed PC protein may promote tumor growth and spread and thus may be a potential therapeutic target.

Customer Reviews (3)

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06/19/2023

    With the use of PC, the experiment is highly reproducible and convenient for data analysis.

    01/11/2022

      It is analyzed by X-ray crystallography or other crystallization techniques, and has good crystallization properties.

      08/05/2021

        It has a short half-life and high clearance.

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