Recombinant Human PC, GST-tagged
Cat.No. : | PC-1545H |
Product Overview : | Recombinant Human PC protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 828-1178aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | PC pyruvate carboxylase [ Homo sapiens ] |
Official Symbol : | PC |
Synonyms : | PC; pyruvate carboxylase; pyruvate carboxylase, mitochondrial; PCB; pyruvic carboxylase; |
Gene ID : | 5091 |
mRNA Refseq : | NM_000920 |
Protein Refseq : | NP_000911 |
MIM : | 608786 |
UniProt ID : | P11498 |
Chromosome Location : | 11q13.4-q13.5 |
Pathway : | Alanine and aspartate metabolism, organism-specific biosystem; Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Gluconeogenesis, organism-specific biosystem; Glucose metabolism, organism-specific biosystem; Glycolysis and Gluconeogenesis, organism-specific biosystem; |
Function : | ATP binding; biotin binding; biotin carboxylase activity; carboxylic acid binding; ligase activity; metal ion binding; nucleotide binding; pyruvate carboxylase activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe structure of the PC protein determines its ability and stability to bind to DNA. The study of its structure can help us understand its function and mechanism of action.
Therapeutic strategies for PC protein may include inhibiting its expression, blocking its binding to DNA, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.
In cancer, PC proteins may play a role by promoting processes such as DNA replication, repair, and regulation of the cell cycle, thus promoting tumor growth and spread. It could be a potential target for cancer treatment.
Drug development targeting PC proteins needs to consider their specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
The proteins can interact with a variety of other proteins, including DNA repair enzymes, cell cycle regulators, and more. These interactions allow it to regulate the regulatory processes of DNA replication, repair and the cell cycle.
Recently published articles indicate that the expression level of PC protein is related to the occurrence and development of certain cancers. The highly expressed PC protein may promote tumor growth and spread and thus may be a potential therapeutic target.
Customer Reviews (3)
Write a reviewWith the use of PC, the experiment is highly reproducible and convenient for data analysis.
It is analyzed by X-ray crystallography or other crystallization techniques, and has good crystallization properties.
It has a short half-life and high clearance.
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