Recombinant Human Scavenger Receptor Class B, Member 1, Fc-His
Cat.No. : | SCARB1-852H |
Product Overview : | A DNA sequenceencoding the mature form of human SCARB1 extracellular domain (Pro 33 - Tyr 443)was fused with a polyhistidine tag at the C-terminus. |
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Cat. No. : | SCARB1-852H |
Description : | SCARB1 is a member of the scavenger receptorfamily. SCARB1 is expressed primarily in liver and non-placentalsteroidogenic tissues. It binds high density lipoproteins (LDL) and mediatesselective cholesterol uptake by a mechanism distinct from the LDL pathway.High density lipoproteins (HDLs) play a critical role in cholesterolmetabolism and their plasma concentrations are inversely correlated with riskfor atherosclerosis. SCARB1 is a key component in the reverse cholesteroltransport pathway and plays an important role in lipid metabolism. |
Source : | Human |
Host : | Human Cells |
Form : | Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants beforelyophilization. Specific concentrations are included in the hardcopy of COA. |
Purity : | > 95 % as determined by SDS-PAGE |
Endotoxin : | ﹤1.0 EU per μgprotein as determined by the LAL method |
Stability : | Samplesare stable for up to twelve months from date of receipt at -70°C. |
Predicted N terminal : | Pro 33 |
Molecular Mass : | The recombinanthuman SCARB1 consists of 422 amino acids and has a predicted molecular massof 48 kDa. In SDS-PAGE under reducing conditions, the apparent molecular massof rhSCARB1 is approximately 75-85 kDa due to glycosylation. |
Reconstitution : | A hardcopy of COAwith reconstitution instruction is sent along with the products. |
Storage : | Store it understerile conditions at -70°C upon receiving. Recommend to aliquot the proteininto smaller quantities for optimal storage. Avoid repeated freeze-thawcycles. |
Gene Name : | SCARB1 scavenger receptor class B, member 1[ Homo sapiens ] |
Official Symbol : | SCARB1 |
Synonyms : | SCARB1; scavengerreceptor class B, member 1; CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; CD36 antigen (collagen type I receptor, thrombospondinreceptor)-like 1; CD36 and LIMPII analogous 1; MGC138242; OTTHUMP00000239001;OTTHUMP00000239002; OTTHUMP00000239003; OTTHUMP00000239004;OTTHUMP00000239005; OTTHUMP00000239006; scavenger receptor class Bmember 1; scavenger receptor class B type III; CD36antigen; CD36 antigen-like 1; collagen type I receptor, thrombospondinreceptor-like 1 |
Gene ID : | 949 |
mRNA Refseq : | NM_001082959 |
Protein Refseq : | NP_001076428 |
MIM : | 601040 |
UniProt ID : | Q8WTV0 |
Chromosome Location : | 12q24.31 |
Pathway : | Bile secretion; Fatdigestion and absorption; Folate Metabolism; HDL-mediated lipid transport;Hepatitis C; Lipid digestion, mobilization, and transport; Lipoproteinmetabolism; metabolism; Phagosome; Selenium Pathway; Statin Pathway; VitaminA and carotenoid metabolism; Vitamin digestion and absorption |
Function : | 1-phosphatidylinositolbinding; apolipoprotein A-I binding; apolipoprotein binding; high-densitylipoprotein particle binding; high-density lipoprotein particle receptoractivity; lipopolysaccharide binding; lipopolysaccharide receptor activity;low-density lipoprotein particle binding; phosphatidylserinebinding; protein homodimerization activity; receptor activity;transporter activity |
Products Types
◆ Recombinant Protein | ||
SCARB1-1087H | Recombinant Human SCARB1 Protein (33-443 aa), His-SUMO-tagged | +Inquiry |
SCARB1-436H | Recombinant Human SCARB1 Protein, Fc-tagged | +Inquiry |
Scarb1-699R | Recombinant Rat Scarb1 Protein, His/GST-tagged | +Inquiry |
Scarb1-849M | Recombinant Mouse Scarb1 protein(Pro33-Val440), His-tagged | +Inquiry |
SCARB1-467H | Recombinant Human SCARB1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
SCARB1-2699HCL | Recombinant Human SCARB1 cell lysate | +Inquiry |
SCARB1-2684MCL | Recombinant Mouse SCARB1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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