Recombinant Human TAF1, GST-tagged
| Cat.No. : | TAF1-6954H |
| Product Overview : | Recombinant human TAF1 (1032-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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| Description : | TAF1 is a DNA-binding protein complex required for RNA polymerase II-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells. TAF1 plays a key role in the initiation process, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex and that may be stable through multiple rounds of transcription. TAF1 may be targeted to specific chromatin-bound promoters and may play a key role in chromatin recognition (1). TAF1 also serves to link the control of transcription to the cell cycle. |
| Source : | Sf9 insect cells using baculovirus |
| Species : | Human |
| Tag : | GST |
| Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutahione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Molecular Mass : | ~155 kDa |
| Purity : | The purity of TAF1 was determined to be >70% by densitometry. |
| Applications : | Western Blot |
| Stability : | 1 yr At -70oC from date of shipment. |
| Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1 ug/ul |
| Gene Name : | TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa [ Homo sapiens (human) ] |
| Official Symbol : | TAF1 |
| Synonyms : | TAF1; OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S; NP_004597.2; EC 2.7.11.1; NP_620278.1 |
| Gene ID : | 6872 |
| mRNA Refseq : | NM_138923 |
| Protein Refseq : | NP_620278 |
| MIM : | 313650 |
| UniProt ID : | P21675 |
| Chromosome Location : | Xq13.1 |
| Pathway : | Basal transcription factors; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Transcription |
| Function : | TBP-class protein binding; histone acetyl-lysine binding; protein serine/threonine kinase activity |
Products Types
| ◆ Recombinant Protein | ||
| TAF1-122H | Recombinant Human TAF1, GST-tagged | +Inquiry |
| TAF1-222H | Recombinant Human TAF1 Protein, His-tagged | +Inquiry |
| TAF1-216H | Recombinant Human TAF1 Protein, His-tagged | +Inquiry |
| TAF1-78H | Recombinant Human TAF1, His&FLAG-tagged | +Inquiry |
| TAF1-165H | Recombinant Human TAF1, GST-tagged | +Inquiry |
| ◆ Assay kits | ||
| Kit-1873 | TAF1 (BD1/BD2) Inhibitor Screening Assay Kit | +Inquiry |
| Kit-2032 | TAF1 bromodomain 1 TR-FRET Assay Kit | +Inquiry |
| Kit-2033 | TAF1 bromodomains 1 and 2 TR-FRET Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionTAF1 specifically modulates the expression of certain genes, impacting diverse cellular functions and processes.
TAF1 is pivotal in initiating transcription by RNA polymerase II, regulating the early steps of gene expression.
TAF1 responds to cellular signals and stress, adapting gene expression to meet cellular needs and challenges.
TAF1 plays a role in chromatin remodeling, making DNA accessible for transcription and regulating gene activity.
Changes in TAF1 can influence key cellular processes like the cell cycle and programmed cell death.
TAF1 is integral to the TFIID complex, essential for accurate and efficient transcription initiation.
Mutations in TAF1 are linked to neurodevelopmental disorders, affecting brain development and function.
Customer Reviews (3)
Write a reviewExpertise in peptide synthesis, accelerates our peptide-based research.
Swift protein quantification, improves data reliability in our work.
Reliable protein crystallography, key for our structural biology research.
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