Recombinant Xenopus ube2d2, His-tagged
| Cat.No. : | ube2d2-236X |
| Product Overview : | Recombinant full length Xenopus UBE2D2 (UBC4) was expressed in E. coli cells using an N-terminal His tag. |
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| Description : | UBE2D2(UBC4) Protein or ubiquitin-conjugating enzyme E2D 2 is a member of the E2 ubiquitin-conjugating enzyme family which functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. UBE2D2 specifically ubiquitinates E6AP and in vivo inhibition of UBE2D2 can lead to inhibition of E6-stimulated p53 degradation. UBE2D2 could conjugate ubiquitin to target proteins in an E6AP-dependent manner. |
| Source : | E. coli |
| Species : | Xenopus laevis |
| Tag : | His |
| Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
| Molecular Mass : | ~17 kDa |
| Purity : | >95% by densitometry |
| Applications : | Western Blot |
| Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1 μg/μl |
| Gene Name : | ube2d2?ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [?Xenopus laevis?(African clawed frog) ] |
| Official Symbol : | ube2d2 |
| Synonyms : | ube2d2; ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); EC 6.3.2.- |
| Gene ID : | 446340 |
| mRNA Refseq : | NM_001093036 |
| Protein Refseq : | ?NP_001086505 |
| Pathway : | Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis |
Products Types
| ◆ Recombinant Protein | ||
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| UBE2D2-67H | Recombinant Human UBE2D2 Protein | +Inquiry |
| UBE2D2-243H | Recombinant Human UBE2D2 Protein, His-tagged | +Inquiry |
| UBE2D2-71H | Recombinant Human UBE2D2, His-tagged | +Inquiry |
| UBE2D2-301587H | Recombinant Human UBE2D2 protein, GST-tagged | +Inquiry |
| ◆ Lysates | ||
| UBE2D2-588HCL | Recombinant Human UBE2D2 293 Cell Lysate | +Inquiry |
| UBE2D2-587HCL | Recombinant Human UBE2D2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionUBE2D2 works in tandem with other ubiquitin-proteasome system components, orchestrating protein degradation.
It facilitates the attachment of ubiquitin to target proteins, directing them to the proteasome for breakdown.
UBE2D2 plays a role in controlling the cell cycle by regulating the degradation of key cycle-related proteins.
Targeting UBE2D2 could offer new treatments for conditions involving protein misfolding and aggregation.
Altered UBE2D2 activity is linked with several diseases, including cancer and neurodegenerative disorders.
Genetic mutations in UBE2D2 can disrupt protein turnover, affecting various cellular functions and stability.
UBE2D2, a ubiquitin-conjugating enzyme, is vital for tagging proteins with ubiquitin, marking them for degradation.
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