Recombinant Human WNT3, StrepII-tagged
| Cat.No. : | WNT3-205H |
| Product Overview : | Purified, full-length human recombinant WNT3 protein (amino acids 22-355, 334 a.a.) with StrepII tag, produced in human cells. Predicted molecular weight: 37.5 kDa. (Accession NP_110380.1; UniProt P56703) |
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| Description : | The WNT family consists of structurally related signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This protein is a member of the WNT gene family which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. |
| Source : | Human Cells |
| Species : | Human |
| Tag : | StrepII |
| Form : | Lyophilized from sterile 0.2μm filtered solution in 0.3X PBS with 10% Trehalose (carrier-free). |
| Protein length : | 22-355, 334 a.a. |
| AA Sequence : | GYPIWWSLALGQQYTSLGSQPLLCG SIPGLVPKQLRFCRNYIEIMPSVAE GVKLGIQECQHQFRGRRWNCTTIDD SLAIFGPVLDKATRESAFVHAIASA GVAFAVTRSCAEGTSTICGCDSHHK GPPGEGWKWGGCSEDADFGVLVSRE FADARENRPDARSAMNKHNNEAGRT TILDHMHLKCKCHGLSGSCEVKTCW WAQPDFRAIGDFLKDKYDSASEMVV EKHRESRGWVETLRAKYSLFKPPTE RDLVYYENSPNFCEPNPETGSFGTR DRTCNVTSHGIDGCDLLCCGRGHNT RTEKRKEKCHCIFHWCCYVSCQECI RIYDVHTCK |
| Endotoxin : | <0.1 eu per ug protein by lal |
| Purity : | >95% pure by SDS-PAGE |
| Storage : | 12 months at -20°C as supplied; 1 month at 4°C after reconstitution. Avoid freeze/thaw cycles. |
| Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in PBS to a concentration of 0.1 mg/ml. |
| Gene Name : | WNT3 wingless-type MMTV integration site family, member 3 [ Homo sapiens ] |
| Official Symbol : | WNT3 |
| Synonyms : | WNT3; wingless-type MMTV integration site family, member 3; INT4; proto-oncogene Wnt-3; MGC131950; MGC138321; MGC138323; WNT 3 proto oncogene protein; WNT-3 proto-oncogene protein; proto-oncogene Int-4 homolog; |
| Gene ID : | 7473 |
| mRNA Refseq : | NM_030753 |
| Protein Refseq : | NP_110380 |
| MIM : | 165330 |
| UniProt ID : | P56703 |
| Chromosome Location : | 17q21-q22 |
| Pathway : | Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; |
| Function : | frizzled binding; frizzled-2 binding; protein domain specific binding; receptor agonist activity; |
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| ◆ Recombinant Protein | ||
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| WNT3-5164M | Recombinant Mouse WNT3 Protein, His-tagged | +Inquiry |
| WNT3-5160M | Active Recombinant Mouse WNT3 | +Inquiry |
| ◆ Lysates | ||
| WNT3-296HCL | Recombinant Human WNT3 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionResearchers are exploring various approaches, including small molecules and biologics, to modulate WNT3 signaling for therapeutic benefits.
WNT3 can promote tissue regeneration by activating stem cells and facilitating tissue repair processes.
WNT3 can be explored in tissue engineering to enhance the development and integration of engineered tissues and organs.
WNT3 holds promise in regenerative medicine for its potential to enhance tissue regeneration, but more research is needed for practical applications.
Clinical trials may be investigating the role of WNT3 and related pathways in various diseases, but you would need to check the latest clinical trial databases for specific studies.
Customer Reviews (3)
Write a reviewI am extremely satisfied with the high performance and the exceptional support associated with this protein, as it has greatly contributed to the success of my scientific endeavors.
Their expertise and prompt assistance have been instrumental in overcoming challenges and optimizing the use of the WNT3 protein in my studies.
the manufacturer's commitment to delivering excellent technical support has proven to be invaluable in troubleshooting any issues that arose during my experiments.
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