Name: Recombinant Human Glycogen [starch] synthase, liver (GYS2)
Brand: CUSABIO
SKU: 010079HU

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GYS2

Uniprot No.

P54840

Alternative Names

EC 2.4.1.11; Glycogen [starch] synthase; Glycogen starch synthase liver; Glycogen synthase 2 liver; Gys2; GYS2_HUMAN; liver

Species

Homo sapiens (Human)

Expression Region

1-703

Target Protein Sequence

MLRGRSLSVT SLGGLPQWEV EELPVEELLL FEVAWEVTNK VGGIYTVIQT KAKTTADEWG ENYFLIGPYF EHNMKTQVEQ CEPVNDAVRR AVDAMNKHGC QVHFGRWLIE GSPYVVLFDI GYSAWNLDRW KGDLWEACSV GIPYHDREAN DMLIFGSLTA WFLKEVTDHA DGKYVVAQFH EWQAGIGLIL SRARKLPIAT IFTTHATLLG RYLCAANIDF YNHLDKFNID KEAGERQIYH RYCMERASVH CAHVFTTVSE ITAIEAEHML KRKPDVVTPN GLNVKKFSAV HEFQNLHAMY KARIQDFVRG HFYGHLDFDL EKTLFLFIAG RYEFSNKGAD IFLESLSRLN FLLRMHKSDI TVMVFFIMPA KTNNFNVETL KGQAVRKQLW DVAHSVKEKF GKKLYDALLR GEIPDLNDIL DRDDLTIMKR AIFSTQRQSL PPVTTHNMID DSTDPILSTI RRIGLFNNRT DRVKVILHPE FLSSTSPLLP MDYEEFVRGC HLGVFPSYYE PWGYTPAECT VMGIPSVTTN LSGFGCFMQE HVADPTAYGI YIVDRRFRSP DDSCNQLTKF LYGFCKQSRR QRIIQRNRTE RLSDLLDWRY LGRYYQHARH LTLSRAFPDK FHVELTSPPT TEGFKYPRPS SVPPSPSGSQ ASSPQSSDVE DEVEDERYDE EEEAERDRLN IKSPFSLSHV PHGKKKLHGE YKN

Protein Length

Full length protein

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

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Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

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■ Q&A

Regarding your protein CSB-EP010079HU, do you know if any customer has provided feedback about this protein being active?

Very nice to receive your inquiry. Sorry, as this is a semi-customized protein, which means we have never expressed any of these proteins before, so also haven't tested the activity, we can't 100% guarantee its activity.
However, as what we provide is the full length protein, and it's purified under very mild condition to avoid the activity loss, we recommend you to purchase a small size of eukaryotic expressed protein to have a try.
Generally, the more advanced expression system the protein is expressed with, the more likely to be active. Sorry, we haven't received any feedback about the activity of this protein.
Here is a literature for your reference: https://www.researchgate.net/publication/221736849_AMP-activated_protein_kinase_phosphorylates_and_inactivates_liver_glycogen_synthase

Target Background

Function

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

Gene References into Functions

Mutation in GYS2 gene is associated with hepatic glycogen synthase deficiency. PMID: 28245189
Sequencing of the GYS2 gene is more likely to be positive in patients with fasting ketotic hypoglycaemia and concomitant postprandial hyperglycaemia with hyperlactataemia. PMID: 23426827
The GYS2 gene is a new susceptibility gene that significantly affects the risk for ovary syndrome through obesity-related conditions. PMID: 22951595

Involvement in disease

Glycogen storage disease 0 (GSD0)

Protein Families

Glycosyltransferase 3 family

Database Links

HGNC: 4707

OMIM: 138571

KEGG: hsa:2998

STRING: 9606.ENSP00000261195

UniGene: Hs.82614

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Recombinant Human Glycogen [starch] synthase, liver (GYS2)

Product Details

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Customer Reviews and Q&A

Target Background

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