CLOCK

Gene Symbol CLOCK
Entrez Gene 9575
Alt Symbol KAT13D, bHLHe8
Species Human
Gene Type protein-coding
Description clock circadian regulator
Other Description circadian locomoter output cycles kaput protein|circadian locomoter output cycles protein kaput|class E basic helix-loop-helix protein 8|clock homolog
Swissprots A0AV01 Q9UIT8 O14516 A2I2N9 O15516
Accessions AAF70307 ABM64208 BAB88852 BAB92020 EAX05468 O15516 AB002332 BAA20792 AB005535 BAA21774 AF011568 AAB83969 AK096319 AK124437 AK223549 BAD97269 AK291708 BAF84397 BC040570 BC041878 AAH41878 BC126157 AAI26158 BC126159 AAI26160 BX537616 BX538337 DA658950 EU446690 ABZ92219 HQ258670 ADR83421 XM_005265787 XP_005265844 XM_006714054 XP_006714117 XM_011534409 XP_011532711 XM_011534410 XP_011532712 XM_011534411 XP_011532713 NM_001267843 NP_001254772 NM_004898 NP_004889
Function Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
Subcellular Location Nucleus {ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23160374}. Cytoplasm {ECO:0000250|UniProtKB:O08785}. Note=Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL/BMAL1-dependent. Phosphorylated form located in the nucleus while the nonphosphorylated form found only in the cytoplasm. Sequestered to the cytoplasm in the presence of ID2 (By similarity). Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250|UniProtKB:O08785, ECO:0000269|PubMed:21659603}.
Tissue Specificity Hair follicles (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN). {ECO:0000269|PubMed:10198158, ECO:0000269|PubMed:24005054}.
Top Pathways Circadian rhythm, Herpes simplex infection, Dopaminergic synapse

Clock CRISPR/Cas9 KO Plasmid (h) - sc-401261 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock HDR Plasmid (h) - sc-401261-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock Double Nickase Plasmid (h) - sc-401261-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock Double Nickase Plasmid (h2) - sc-401261-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock CRISPR Activation Plasmid (h) - sc-401261-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock CRISPR Activation Plasmid (h2) - sc-401261-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock Lentiviral Activation Particles (h) - sc-401261-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock Lentiviral Activation Particles (h2) - sc-401261-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Clock siRNA (h) - sc-35074 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Clock shRNA Plasmid (h) - sc-35074-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Clock shRNA (h) Lentiviral Particles - sc-35074-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Clock siRNA (chicken) - sc-63267 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Bird

Clock shRNA Plasmid (chicken) - sc-63267-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Bird

CLOCK RNAi - H00009575-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU056991 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6253 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CLOCK siRNA (Human) - CRH6370 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLOCK - MBS8239724 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLOCK (NM_004898.3) - SHH265553 from Creative biogene

Category siRNA
Species Reactivities Human

CLOCK shRNA Plasmid (Human) - CHH6370 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLOCK miRNA 3'UTR clone - MiUTR4H-TG02188 from Creative biogene

Species Reactivities Human
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