| Gene Symbol |
AACS
|
| Entrez Gene |
65985
|
| Alt Symbol |
ACSF1, SUR-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acetoacetyl-CoA synthetase
|
| Other Description |
acetoacetate-CoA ligase|acyl-CoA synthetase family member 1|homolog of C. elegans supressor of ras 5 (sur-5)|protein sur-5 homolog
|
| Swissprots |
Q8IWD2 Q9BSJ9 Q8NEW5 Q49AC3 Q49AB9 Q658Q8 Q86V21 Q9H829 Q9HA19
|
| Accessions |
CCQ43707 EAW98473 EAW98474 EAW98475 Q86V21 AB054121 BAD22560 AK022451 BAB14040 AK022740 BAB14216 AK024036 BAB14793 AK024760 BAB14991 AK123245 AK304176 BAG65058 AK308779 AL833047 CAH56309 AY091468 AAM44124 BC004997 AAH04997 BC036694 AAH36694 BC040490 AAH40490 BC040574 AAH40574 BC041000 AAH41000 BC051862 AAH51862 XM_005253609 XP_005253666 XM_005253610 XP_005253667 XM_005253611 XP_005253668 XM_011538692 XP_011536994 XR_242960 NM_023928 NP_076417
|
| Function |
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in kidney, heart and brain, but low in liver. {ECO:0000269|PubMed:12623130}.
|
| Top Pathways |
Valine, leucine and isoleucine degradation, Butanoate metabolism
|