PNN

Gene Symbol	PNN
Entrez Gene	5411
Alt Symbol	DRS, DRSP, SDK3, memA
Species	Human
Gene Type	protein-coding
Description	pinin, desmosome associated protein
Other Description	140 kDa nuclear and cell adhesion-related phosphoprotein|SR-like protein|desmosome-associated protein|domain-rich serine protein|melanoma metastasis clone A protein|neutrophil protein|nuclear protein SDK3|pinin
Swissprots	Q9UQR9 Q7KYL1 Q99738 Q9H307 B4DZX8 Q6P5X4 Q53EM7 O60899 Q9UHZ9
Accessions	AAG33941 CBJ05784 CBJ21236 EAW65820 Q9H307 AK223612 BAD97332 AK292579 BAF85268 AK300164 BAG61946 AK303136 BAG64240 AK304622 BAG65404 BC062602 AAH62602 BG057344 BM850066 BQ938918 CD687183 U59479 AAB03391 U77718 AAB48304 Y09703 CAA70874 NM_002687 NP_002678
Function	Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-
Subcellular Location	Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
Tissue Specificity	Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors. {ECO:0000269|PubMed:10095061, ECO:0000269|PubMed:8922384, ECO:0000269|PubMed:9447706}.
Top Pathways	RNA transport, mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Pinin peptide - ab89383 from Abcam Category Peptide

Human Pinin protein fragment - ab114826 from Abcam Category Protein Source Wheat germ Species Human

PNN / Pinin Antibody Blocking Peptide - LS-E1065 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNN / Pinin Antibody Blocking Peptide - LS-E20469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNN / Pinin Antibody Blocking Peptide - LS-E20470 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PNN / Pinin Antibody Blocking Peptide - LS-E22582 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Pinin Protein - H00005411-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PNN-Antibody-Center-Blocking-peptide - BP11555c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PNN Blocking Peptide - 33R-5794 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PNN Blocking Peptide - 33R-8164 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Pinin / PNN - H00005411-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Pinin / PNN - H00005411-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PNN fusion protein - ag6643 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PNN - PNN-30966TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Pinin(PNN) - CSB-YP863966HU CSB-EP863966HU CSB-BP863966HU CSB-MP863966HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Pinin (PNN), Recombinant Protein - MBS1381307 from MyBioSource Category Protein Prices $1,525.00, $1,525.00, $1,755.00, $1,755.00, $2,615.00, $2,615.00, $3,055.00, $3,055.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Pinin Protein - NBP1-87784PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Neutrophil Elastase protein - 30-1191S from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg

PNN Peptide, Human - M34GP12032H from Creative Peptides Category Peptide Source Synthetic. Species Human

Search more