| Gene Symbol | CAMK2A |
|---|---|
| Entrez Gene | 815 |
| Alt Symbol | CAMKA |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium/calmodulin-dependent protein kinase II alpha |
| Other Description | CaM kinase II alpha subunit|CaM-kinase II alpha chain|CaMK-II alpha subunit|CaMKIINalpha|caM kinase II subunit alpha|caMK-II subunit alpha|calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha|calcium/calmodulin-dependent protein kinase II alpha-B subunit|calcium/calmodulin-dependent protein kinase type II alpha chain|calcium/calmodulin-dependent protein kinase type II subunit alpha |
| Swissprots | Q9Y352 Q9UQM7 Q9Y2H4 Q9UL21 |
| Accessions | ABD59008 EAW61741 EAW61742 Q9UQM7 AB023185 BAA76812 AF091486 AAD55815 AF145710 AAD30558 AF145711 AAD30559 AK289776 BAF82465 AK308853 AY429524 BC040457 AAH40457 BF951952 EU832105 ACE87455 EU832199 ACE86769 NM_015981 NP_057065 NM_171825 NP_741960 |
| Function | CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic lipid rafts. {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels |