CAMK2A

Gene Symbol CAMK2A
Entrez Gene 815
Alt Symbol CAMKA
Species Human
Gene Type protein-coding
Description calcium/calmodulin-dependent protein kinase II alpha
Other Description CaM kinase II alpha subunit|CaM-kinase II alpha chain|CaMK-II alpha subunit|CaMKIINalpha|caM kinase II subunit alpha|caMK-II subunit alpha|calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha|calcium/calmodulin-dependent protein kinase II alpha-B subunit|calcium/calmodulin-dependent protein kinase type II alpha chain|calcium/calmodulin-dependent protein kinase type II subunit alpha
Swissprots Q9Y352 Q9UQM7 Q9Y2H4 Q9UL21
Accessions ABD59008 EAW61741 EAW61742 Q9UQM7 AB023185 BAA76812 AF091486 AAD55815 AF145710 AAD30558 AF145711 AAD30559 AK289776 BAF82465 AK308853 AY429524 BC040457 AAH40457 BF951952 EU832105 ACE87455 EU832199 ACE86769 NM_015981 NP_057065 NM_171825 NP_741960
Function CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). {ECO:0000250}.
Subcellular Location Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic lipid rafts. {ECO:0000250}.
Top Pathways Wnt signaling pathway, Glucagon signaling pathway, Adrenergic signaling in cardiomyocytes, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

Phospho-CaMKII (Thr286) Antibody - 3361 from Cell Signaling Technology

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Neuro2A cells treated with calcium ionophore (A23187, 2 µM) after a 20-minute preincubation with forskolin (30 μM), using Phospho-CaMKII (Thr286) Antibody (upper) or CaMKII Antibody #3362 (lower).

Phospho-CaMKII (Tyr231) Antibody - 3356 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat brain, either sham-operated, 15 min ischemia followed by 4 h reperfusion or 15 min ischemia only, using Phospho-CaMKII (Tyr231) Antibody (upper) or CaMKII Antibody (lower).

Phospho-CaMKII (Thr286) (D21E4) Rabbit mAb - 12716 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D21E4
Western blot analysis of extracts from MKN-45 cells treated with λ-phosphatase or Forskolin #3828 (30 μM, 20 min) using Phospho-CaMKII (Thr286) (D21E4) Rabbit mAb (upper) and CaMKII-α (D10C11) Rabbit mAb #11945 (lower).

CaMKII-α (D10C11) Rabbit mAb - 11945 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10C11
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc-tagged full-length human CaMKII-α (hCaMKII-α-Myc;+), CaMKII-β (hCaMKII-β-Myc;+), or CaMKII-δ (hCaMKII-δ-Myc;+), and mouse brain using CaMKII-α (D10C11) Rabbit mAb (upper) or Myc-Tag (71D10) Rabbit mAb #2278 (lower).

CaMKII (pan) (D11A10) Rabbit mAb - 4436 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11A10
Western blot analysis of extracts from 293T cells, mock transfected (lane 1) or expressing CaMKII-α (lane2), CaMKII-β (lane 3) or CaMKII-γ (lane 4) using CaMKII (pan) (D11A10) Rabbit mAb.

CaMKII (pan) Antibody - 3362 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from rat and mouse brain using CaMKII (pan) Antibody.

CaMKII-α Antibody - 3357 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, mock transfected (lane 1) or expressing CaMKII-α (lane2), CaMKII-β (lane 3) or CaMKII-γ (lane 4) using CaMKII-α Antibody (upper) and CaMKII (pan) (D11A10) Rabbit mAb #4436 (lower).

CaMKII (H-300) - sc-13082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CaMKII (H-300): sc-13082. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse brain tissue showing cytoplasmic localization.

CaMKII (G-1) - sc-5306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKII (G-1): sc-5306. Western blot analysis of CaMKII expression in mouse brain tissue extract.

CaMKII (M-176) - sc-9035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CaMKII (M-176): sc-9035. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

CaMKIIα (A-1) - sc-13141 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIIα (A-1): sc-13141. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human muscle tissue showing cytoplasmic staining.

CaMKIIα (B-2) - sc-55508 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIIα (B-2): sc-55508. Western blot analysis of CaMKIIα expression in mouse brain (A) and rat brain (B) tissue extracts.

CaMKIIα (I-16) - sc-5390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKIIα (I-16): sc-5390. Western blot analysis of CaMKIIα expression in mouse brain tissue extract.

CaMKIIα (L-15) - sc-5391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKIIα (L-15): sc-5391. Western blot analysis of CaMKIIα expression in mouse brain extract.

CaMKIIα (45) - sc-136212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
CaMKIIα (45): sc-136212. Western blot analysis of CaMKIIα expression in IMR-32 (A) and U-87 MG (B) whole cell lysates.

CaMKIIβ (D-6) - sc-376828 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CaMKIIβ (D-6): 376828. Western blot analysis of CaMKIIβ expression in mouse brain tissue extract.

CaMKIIβ (C-20) - sc-1540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CaMKIIβ (C-20): sc-1540. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing cytoplasmic staining of Purkinje cells and neuropil staining in granular and molecular layers.

p-CaMKIIα (Thr 286)-R - sc-12886-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
p-CaMKIIα (Thr 286)-R: sc-12886-R. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic staining.

Anti-CAMK2A + CAMK2B + CAMK2D (phospho T305) antibody - ab195916 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CAMK2A + CAMK2B + CAMK2D (phospho T305) antibody (ab195916) at 1/500 dilutionLane 1 : NIH-3T3 whole cell lysates with antigen specific peptideLane 2 : NIH-3T3 whole cell lysatesLysates/proteins at 12.5 µg per lane.

Anti-CAMK2A + CAMK2B + CAMK2D antibody - ab110881 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab110881, at a 1/50 dilution, staining CAMK2A + CAMK2B + CAMK2D in paraffin-embedded Human brain tissue by Immunohistochemistry, in the absence (left panel) or presence (right panel) of the immunizing peptide.

Anti-CaMKII (phospho T286) antibody - ab195935 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CaMKII (phospho T286) antibody (ab195935) at 1/500 dilutionLane 1 : K562 whole cell lysate with antigen-specific peptideLane 2 : K562 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-CaMKII (phospho T286) antibody [22B1] - ab171095 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 22B1
Immunofluorescence analysis of U251 cells labeling phosphorylated CaMKII (green) with ab171095 at a 1/100 dilution. Nuclei are stained (blue).

Anti-CaMKII alpha (phospho T286) antibody [22B1] - ab2724 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 22B1
ICC/IF image of ab2724 stained Hep cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab2724, 5µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-CaMKII alpha (phospho T286) antibody [EPR1830] - ab124880 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1830
All lanes : Anti-CaMKII alpha (phospho T286) antibody [EPR1830] (ab124880) at 1/1000 dilutionLane 1 : Rat brain lysate untreatedLane 2 : Rat brain lysate treated with Lambda PhosphataseLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CaMKII alpha antibody - ab87597 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-CaMKII alpha antibody (ab87597) at 0.1 µg/ml + mouse brain lysate at 35 µgdeveloped using the ECL technique
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