| Gene Symbol |
sad
|
| Entrez Gene |
44858
|
| Alt Symbol |
315a1, CG14728, CYP315A1, Cyp315a1, Dmel\CG14728, Sad
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
shadow
|
| Other Description |
CG14728-PA|cytochrome P450|ecdysteroid hydroxylase|karmoisin ghost|sad-PA
|
| Swissprots |
Q9VGH1 Q5U131 Q8MTR7
|
| Accessions |
AAF54711 Q9VGH1 BT016061 AAV36946 NM_141866 NP_650123
|
| Function |
Required for CNS development: midline glial cells. Involved in the metabolism of insect hormones: responsible for ecdysteroid C2-hydroxylase activity. May be involved in the breakdown of synthetic insecticides. {ECO:0000269|PubMed:12177427}.
|
| Subcellular Location |
Mitochondrion membrane {ECO:0000269|PubMed:14610274}.
|
| Tissue Specificity |
Complex coexpression pattern of dib (disembodied) and sad (shade) in the early embryo that restricts to the prothoracic gland cells of the developing ring gland during late embryogenesis. In larvae and adult, coexpression is seen in prothoracic gland and follicle cells of the ovary. In adults, coexpression is seen in the follicle cells, sad only is expressed in nurse cells. {ECO:0000269|PubMed:12177427}.
|
| Top Pathways |
Insect hormone biosynthesis
|