CASP14

Gene Symbol CASP14
Entrez Gene 23581
Alt Symbol -
Species Human
Gene Type protein-coding
Description caspase 14, apoptosis-related cysteine peptidase
Other Description CASP-14|apoptosis-related cysteine protease|caspase 14, apoptosis-related cysteine protease|caspase-14
Swissprots O95823 Q3SYC9 P31944
Accessions EAW84459 P31944 AF097874 AAD16173 AK313992 BAG36704 BC069541 AAH69541 BC103868 AAI03869 BC103869 AAI03870 BM840054 EU262664 ABX83060 EU502748 ACA63845 HQ448424 ADQ32904 XM_011527861 XP_011526163 NM_012114 NP_036246
Function Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Nucleus.
Tissue Specificity Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. {ECO:0000269|PubMed:11175259}.

Caspase-14 Antibody - 8519 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from mouse and rat skin using Caspase-14 Antibody.

caspase-14 (32) - sc-136351 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CASPASE-14 (32): sc-136351. Western blot analysis of CASPASE-14 expression in mouse tissue extract.

caspase-14 (D-10) - sc-48336 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-14 (D-10): sc-48336. Immunoperoxidase staining of formalin fixed, paraffin-embedded vagina tissue showing cytoplasmic and nuclear staining of surface epthelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

caspase-14 (H-99) - sc-5628 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
caspase-14 (H-99): sc-5628. Western blot analysis of human recombinant caspase-14.

caspase-14 (C-12) - sc-48395 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
caspase-14 (C-12): sc-48395. Western blot analysis of human recombinant procaspase-14.

caspase-14 (70A1426) - sc-56040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

caspase-14 p10 (C-20) - sc-9644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-14 p10 (C-20): sc-9644. Western blot analysis of human recombinant procaspase-14.

caspase-14 p10 (R-18) - sc-9642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-14 p10 (R-18): sc-9642. Western blot analysis of human recombinant procaspase-14.

caspase-14 p20 (M-21) - sc-9641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
caspase-14 p20 (M-21): sc-9641. Western blot analysis of human recombinant procaspase-14.

Anti-Caspase-14 antibody - ab45415 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab45415 stained HepG2 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab45415 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1:200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 100% methanol fixed (5min) HeLa cells at 5ug/ml.

Anti-Caspase-14 antibody - ab139741 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Caspase-14 staining in Human normal skin formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab139741, 0.5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Caspase-14 antibody - ab97319 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Caspase-14 antibody (ab97319) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-Caspase-14 antibody - ab115275 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Staining of Caspase-14 in Human skin tissue (formalin fixed, paraffin embedded), using ab115275 at 5 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Caspase-14 antibody - ab26991 from Abcam

Prices $372.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Caspase-14 antibody - ab57168 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Caspase-14 antibody [70A1426] - ab11920 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 70A1426

Anti-Caspase-14 antibody [EPR12927] - ab174847 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12927
All lanes : Anti-Caspase-14 antibody [EPR12927] (ab174847) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : ECV-304 cell lysateLane 3 : HACAT cell lysateLane 4 : Human skin lysateLysates/proteins at 10 µg per lane.

Anti-CASP14 / Caspase 14 Antibody (C-Terminus) IHC-plus™ - LS-B474 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Caspase 14 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B474 concentration 5 ug/ml.

Anti-CASP14 / Caspase 14 Antibody (aa223-242) - LS-C313222 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
CASP14 / Caspase 14 antibody. IHC(P): Human Esophagus Squama Cancer Tissue.

Anti-CASP14 / Caspase 14 Antibody (N-Terminus) - LS-C77971 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CASP14 / Caspase 14 Antibody - LS-C77969 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-CASP14 / Caspase 14 Antibody - LS-C83964 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-CASP14 / Caspase 14 Antibody (N-Terminus) - LS-C153288 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASP14 / Caspase 14 Antibody (aa1-257, Biotin) - LS-C298820 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CASP14 / Caspase 14 Antibody (aa1-257, FITC) - LS-C301728 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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