| Gene Symbol | PARP1 |
|---|---|
| Entrez Gene | 142 |
| Alt Symbol | ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | poly (ADP-ribose) polymerase 1 |
| Other Description | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)|ADP-ribosyltransferase NAD(+)|ADP-ribosyltransferase diphtheria toxin-like 1|NAD(+) ADP-ribosyltransferase 1|poly (ADP-ribose) polymerase family, member 1|poly [ADP-ribose] polymerase 1|poly(ADP-ribose) polymerase|poly(ADP-ribose) synthetase|poly(ADP-ribosyl)transferase|poly[ADP-ribose] synthase 1 |
| Swissprots | B1ANJ4 P09874 Q8IUZ9 |
| Accessions | AAA51663 AAA60000 AAM75364 CAA34663 CAA39606 CBX74363 EAW69783 EAW69784 EAW69785 P09874 AF401218 AAL02174 AK125650 AK225654 AK303340 BAG64403 AK312339 BAG35260 BC008660 BC014206 AAH14206 BC018620 AAH18620 BC021045 BC037545 AAH37545 DB097441 DQ891636 ABM82562 DQ894826 ABM85752 J03473 AAB59447 M17081 AAA51599 M18112 AAA60137 M32721 AAA60155 NM_001618 NP_001609 |
| Function | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. {ECO:0000269|PubMed:17177976, E |
| Subcellular Location | Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage. |
| Top Pathways | Base excision repair |