KRAS

Gene Symbol KRAS
Entrez Gene 3845
Alt Symbol C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
Species Human
Gene Type protein-coding
Description Kirsten rat sarcoma viral oncogene homolog
Other Description GTPase KRas|K-Ras 2|K-ras p21 protein|PR310 c-K-ras oncogene|c-Ki-ras|c-Kirsten-ras protein|cellular c-Ki-ras2 proto-oncogene|oncogene KRAS2|transforming protein p21|v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog
Swissprots A8K8Z5 Q96D10 P01116 P01118 B0LPF9
Accessions AAA36148 AAA36149 AAA36554 AAB59444 AAB59445 AAD13953 AAF91482 ABP96992 ABP97009 ABP97013 ABP97015 ABS10683 ABS10684 ABY87538 ADQ00188 AFF18187 AGC09594 CAA25828 CAA26593 CBK51852 CBK51925 CBV35640 CDL93479 EAW96511 EAW96512 EAW96513 EAW96514 P01116 AA812162 AF493917 AAM12631 AI539465 AK292510 BAF85199 AW117295 BC010502 BC013572 AAH13572 BC029545 BG258021 BT007153 AAP35817 CD245555 DQ890649 ABM81575 DQ893829 ABM84755 M17087 AAA36555 M35504 AAA35689 M35505 AAA35690 M54968 AAB41942 XM_006719069 XP_006719132 XM_011520653 XP_011518955 NM_004985 NP_004976 NM_033360 NP_203524
Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). {ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:23698361}; Lipid-anchor {ECO:0000305|PubMed:23698361}; Cytoplasmic side {ECO:0000305|PubMed:23698361}. Cytoplasm, cytosol {ECO:0000269|PubMed:23698361}.
Top Pathways Axon guidance, Tight junction, VEGF signaling pathway, Gap junction, Natural killer cell mediated cytotoxicity

K-Ras siRNA (h) - sc-35731 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

K-Ras shRNA Plasmid (h) - sc-35731-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

K-Ras shRNA (h) Lentiviral Particles - sc-35731-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

K-Ras CRISPR/Cas9 KO Plasmid (h) - sc-416674 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras HDR Plasmid (h) - sc-416674-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras Double Nickase Plasmid (h) - sc-416674-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras Double Nickase Plasmid (h2) - sc-416674-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras CRISPR Activation Plasmid (h) - sc-416674-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras CRISPR Activation Plasmid (h2) - sc-416674-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras Lentiviral Activation Particles (h) - sc-416674-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras Lentiviral Activation Particles (h2) - sc-416674-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

K-Ras-2A siRNA (h2) - sc-43874 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

K-Ras-2A shRNA Plasmid (h2) - sc-43874-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

K-Ras-2A shRNA (h2) Lentiviral Particles - sc-43874-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU114431 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg
<B>Immunoblotting</B><BR/>KRAS: <B>Cat. No. EHU114431</B>: Western blot analysis of KRAS in HeLa cells.<BR/><B>Lanes</B><BR/>1. HeLa cells transfected with Renilla Luciferase esiRNA (RLUC, <B>Cat. No. EHURLUC</B>) as negative control.<BR/>2. HeLa cells transfected with KRAS esiRNA (<B>Cat. No. EHU114431</B>). Quantitative-Immunoblotting: Lysates were separated on SDS-Page and probed with mouse Monoclonal Anti-c-K-Ras (1:100) Clone: 234-4.2 (<B>Cat. No. R3400</B>) and goat Anti-GAPDH (1:7000) (Acris) antibodies. The signal intensities of indicated bands were quantified using an Odyssey infrared imaging system (Li-COR) and normalized to the GAPDH signal. At 72h post transfection, a 73% KRAS protein reduction was measured between the negative control RLUC and the sample treated with KRAS esiRNA.

CompoZr® Knockout ZFN Kit - CKOZFN2256 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2256 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KRAS siRNA (Human) - CRH2607 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KRAS RNAi - H00003845-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

KRAS RNAi - H00003845-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human KRAS (NM_004985.3) - SHH327099 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KRAS(NM_033360.2) - SHL204510 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KRAS(NM_004985.3) - SHL204570 from Creative biogene

Category siRNA
Species Reactivities Human

Human KRAS siRNA - orb263109 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KRAS shRNA Plasmid (Human) - CHH2607 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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